The first case of mitoxantrone exposure in early pregnancy

Maria De Santis, Anna Franca Cavaliere, Alessandro Caruso, Giuseppe Straface, Paolo Rosati, Anna Paola Batocchi

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Mitoxantrone is an antineoplastic agent considered a potential human teratogen because of its mechanism of action and is classified by the US Food and Drug Administration in pregnancy category risk D. In the literature there are only four cases of women exposed to the drug in late pregnancy. We report the first case of mitoxantrone therapy in the first trimester and during the pregnancy. A 41-year-old woman affected with multiple sclerosis, conceived during therapy and continued mitoxantrone until 29 weeks and 3 days of her pregnancy. She delivered by cesarean section at 39 weeks a growth restricted female baby weighing 1950g without evidence of congenital malformations.
Original languageEnglish
Pages (from-to)696-697
Number of pages2
JournalNeuroToxicology
Volume28
DOIs
Publication statusPublished - 2007

Keywords

  • Mitoxantrone
  • Multiple Sclerosis
  • Pregnancy

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