The epithelial–mesenchymal transition in cancer: a potential critical topic for translational proteomic research

Roberto Scatena, Maria Antonietta Isgro', Patrizia Bottoni

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The epithelial-mesenchymal transition (EMT) is a morphogenetic process that results in a loss of epithelial characteristics and the acquisition of a mesenchymal phenotype. First described in embryogenesis, the EMT has been recently implicated in carcinogenesis and tumor progression. In addition, recent evidence has shown that stem-like cancer cells present the hallmarks of the EMT. Some of the molecular mechanisms related to the interrelationships between cancer pathophysiology and the EMT are well-defined. Nevertheless, the precise molecular mechanism by which epithelial cancer cells acquire the mesenchymal phenotype remains largely unknown. This review focuses on various proteomic strategies with the goal of better understanding the physiological and pathological mechanisms of the EMT process
Original languageEnglish
Pages (from-to)115-133
Number of pages19
JournalExpert Review of Proteomics
Volume13
DOIs
Publication statusPublished - 2016

Keywords

  • cancer stem cells

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