The Effects of Granulocyte Colony-Stimulating Factor in Patients with a Large Anterior Wall Acute Myocardial Infarction to Prevent Left Ventricular Remodeling: A 10-Year Follow-Up of the RIGENERA Study

Valerio De Stefano, Leonarda Galiuto, Filippo Crea, Antonio Maria Leone, Domenico D'Amario, Francesca Graziani, Eloisa Basile, Andrea Siracusano, Italo Porto, Francesco Canonico, Antonio Giuseppe Rebuzzi, Francesco Cannata, Josip A Borovac, Giuseppe Leone, Gabriella Locorotondo, Rocco Vergallo, Attilio Restivo

Research output: Contribution to journalArticle

Abstract

Background: the RIGENERA trial assessed the efficacy of granulocyte-colony stimulating factor (G-CSF) in the improvement of clinical outcomes in patients with severe acute myocardial infarction. However, there is no evidence available regarding the long-term safety and efficacy of this treatment. Methods: in order to evaluate the long-term effects on the incidence of major adverse events, on the symptom burden, on the quality of life and the mean life expectancy and on the left ventricular (LV) function, we performed a clinical and echocardiographic evaluation together with an assessment using the Minnesota Living with Heart Failure Questionnaire (MLHFQ) and the Seattle Heart Failure Model (SHFM) at 10-years follow-up, in the patients cohorts enrolled in the RIGENERA trial. Results: thirty-two patients were eligible for the prospective clinical and echocardiography analyses. A significant reduction in adverse LV remodeling was observed in G-CSF group compared to controls, 9% vs. 48% (p = 0.030). The New York Heart Association (NYHA) functional class was lower in G-CSF group vs. controls (p = 0.040), with lower burden of symptoms and higher quality of life (p = 0.049). The mean life expectancy was significantly higher in G-CSF group compared to controls (15 ± 4 years vs. 12 ± 4 years, p = 0.046. No difference was found in the incidence of major adverse events. Conclusions: this longest available follow-up on G-CSF treatment in patients with severe acute myocardial infarction (AMI) showed that this treatment was safe and associated with a reduction of adverse LV remodeling and higher quality of life, in comparison with standard-of-care treatment.
Original languageEnglish
Pages (from-to)1214-N/A
JournalJournal of Clinical Medicine
Volume9
DOIs
Publication statusPublished - 2020

Keywords

  • G-CSF
  • granulocyte colony-stimulating factor
  • left ventricular remodeling
  • long-term effects
  • myocardial infarction
  • quality of life

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