[The arrhythmogenicity of alpha 1-adrenergic stimulation following myocardial acidosis]

Translated title of the contribution: [Autom. eng. transl.] [The arrhythmogenicity of alpha 1-adrenergic stimulation following myocardial acidosis]

Giovanni Gambassi, Pierugo Carbonin, Mc Capogrossi

Research output: Contribution to journalArticle

Abstract

Ischemia is associated with myocardial acidosis which recovers upon reperfusion. In such conditions, alpha 1-adrenergic stimulation is arrhythmogenic. We used single cardiac myocytes loaded with the pH fluorescent dye, SNARF-1, to determine if a modulation of pH could explain the effect of alpha 1-adrenergic stimulation. Cells were exposed to acidosis (CO2 15%) for 15 min and then normocapnia restored. During acidosis, alpha 1-adrenergic stimulation caused an increase in pH which was abolished by blocking Na+/H+ exchange with ethylisopropylamiloride (EIPA). After removal of acidosis aftercontractions were manifest in 8 out of 10 and 1 out of 5 cells in the presence of an alpha 1-adrenergic agonist and in control, respectively (p < 0.001). EIPA abolished the occurrence of after contractions. Thus, the arrhythmogenicity of alpha 1-adrenergic stimulation depends on activation of Na+/H+ exchanger.
Translated title of the contribution[Autom. eng. transl.] [The arrhythmogenicity of alpha 1-adrenergic stimulation following myocardial acidosis]
Original languageItalian
Pages (from-to)569-571
Number of pages3
JournalCardiologia
Volume37
Publication statusPublished - 1992

Keywords

  • Acidosis
  • Amiloride
  • Animals
  • Anti-Arrhythmia Agents
  • Arrhythmias, Cardiac
  • Benzopyrans
  • Cardiomyopathies
  • Fluorescence
  • Fluorescent Dyes
  • Heart
  • Hydrogen-Ion Concentration
  • Myocardial Contraction
  • Rats
  • Receptors, Adrenergic, alpha

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