The analgesic agent tapentadol inhibits calcitonin gene-related peptide release from isolated rat brainstem via a serotonergic mechanism

Maria Cristina Greco; Pierluigi Navarra; Giuseppe Tringali

doi:10.1016/j.lfs.2015.12.032

The analgesic agent tapentadol inhibits calcitonin gene-related peptide release from isolated rat brainstem via a serotonergic mechanism

Maria Cristina Greco
, Pierluigi Navarra^*
, Giuseppe Tringali

^*Corresponding author

Research output: Contribution to journal › Article

Abstract

In this study we tested the hypothesis that tapentadol inhibits GGRP release from the rat brainstem through a mechanism mediated by the inhibition of NA reuptake; as a second alternative hypothesis, we investigated whether tapentadol inhibits GGRP release via the inhibition of 5-HT reuptake.

Original language	English
Pages (from-to)	N/A-N/A
Journal	Life Sciences
Issue number	N/A
DOIs	https://doi.org/10.1016/j.lfs.2015.12.032
Publication status	Published - 2015

All Science Journal Classification (ASJC) codes

General Biochemistry,Genetics and Molecular Biology
General Pharmacology, Toxicology and Pharmaceutics

Keywords

5-hydroxytryptamine
Brainstem
Calcitonin gene-related peptide
Ondansetron
Rat
Tapentadol

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10.1016/j.lfs.2015.12.032

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abstract = "In this study we tested the hypothesis that tapentadol inhibits GGRP release from the rat brainstem through a mechanism mediated by the inhibition of NA reuptake; as a second alternative hypothesis, we investigated whether tapentadol inhibits GGRP release via the inhibition of 5-HT reuptake.",

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AU - Navarra, Pierluigi

AU - Tringali, Giuseppe

PY - 2015

Y1 - 2015

N2 - In this study we tested the hypothesis that tapentadol inhibits GGRP release from the rat brainstem through a mechanism mediated by the inhibition of NA reuptake; as a second alternative hypothesis, we investigated whether tapentadol inhibits GGRP release via the inhibition of 5-HT reuptake.

AB - In this study we tested the hypothesis that tapentadol inhibits GGRP release from the rat brainstem through a mechanism mediated by the inhibition of NA reuptake; as a second alternative hypothesis, we investigated whether tapentadol inhibits GGRP release via the inhibition of 5-HT reuptake.

KW - 5-hydroxytryptamine

KW - Brainstem

KW - Calcitonin gene-related peptide

KW - Ondansetron

KW - Rat

KW - Tapentadol

KW - 5-hydroxytryptamine

KW - Brainstem

KW - Calcitonin gene-related peptide

KW - Ondansetron

KW - Rat

KW - Tapentadol

UR - https://publicatt.unicatt.it/handle/10807/70698.6

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JO - Life Sciences

JF - Life Sciences

IS - N/A

ER -

The analgesic agent tapentadol inhibits calcitonin gene-related peptide release from isolated rat brainstem via a serotonergic mechanism

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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