The analgesic agent tapentadol inhibits calcitonin gene-related peptide release from isolated rat brainstem via a serotonergic mechanism

Pierluigi Navarra, Giuseppe Tringali, Maria Cristina Greco

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

In this study we tested the hypothesis that tapentadol inhibits GGRP release from the rat brainstem through a mechanism mediated by the inhibition of NA reuptake; as a second alternative hypothesis, we investigated whether tapentadol inhibits GGRP release via the inhibition of 5-HT reuptake.
Original languageEnglish
Pages (from-to)N/A-N/A
JournalLife Sciences
DOIs
Publication statusPublished - 2015

Keywords

  • 5-hydroxytryptamine
  • Brainstem
  • Calcitonin gene-related peptide
  • Ondansetron
  • Rat
  • Tapentadol

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