The accessory spleen is an important pitfall of 68Ga-DOTANOC PET/CT in the workup for pancreatic neuroendocrine neoplasm

Vittoria Rufini, Guido Rindi, Frediano Inzani, Antonella Stefanelli, Paola Castaldi, Germano Perotti, Annarita Cinquino, Luca Indovina

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objective: The aim of the study was to assess the value and potential pitfalls of 68Ga-DOTANOC positron emission tomography/computed tomography (PET/CT) in patients with suspected pancreatic neuroendocrine neoplasms (pNEN). Methods: Consecutive patients referred for 68Ga-DOTANOC PET/CT for suspected pNENbetweenMay 1, 2011, andOctober 31, 2014, were retrospectively assessed. Scan data were compared with cytological/ histological final diagnosis. Pancreatic neuroendocrine neoplasm detection rate was determined on per-patient and per-lesion basis. Maximum standardized uptake values of lesions were determined. Results: Fifty-eight patients with 65 lesions were enrolled. Twelve patients had nonconfirmed diagnosis; of these, 7 were positive and 5 negative at PET/CT. Of 46 patients with confirmed diagnosis, 36 had pNEN; of these, 33 were positive, 1 negative, and 2 nonevaluable at PET/CT. Ten patients had non-NE lesions, of which 8 were positive, 1 negative, and 1 nonevaluable at PET/CT. Of 48 patients with positive PET/CT, 8 proved to have non-NE lesions, of which 6 were intrapancreatic accessory spleen. No significant maximum standardized uptake values difference was found between pNEN and non-NE lesions. Conclusions: Intrapancreatic accessory spleen is an important pitfall in 68Ga-DOTANOC PET/CT for suspected pNEN. Cytological/histological confirmation is mandatory before any surgical procedure is undertaken.
Original languageEnglish
Pages (from-to)157-163
Number of pages7
JournalPancreas
Volume46
DOIs
Publication statusPublished - 2017

Keywords

  • 68Ga-DOTANOC PET/CT
  • Diagnosis
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Internal Medicine
  • Neuroendocrine neoplasms
  • Spleen

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