The 312N variant of the luteinizing hormone/choriogonadotropin receptor gene (LHCGR) confers up to 2·7-fold increased risk of polycystic ovary syndrome in a Sardinian population

Antonio Capalbo; Francesca Sagnella; Rosanna Apa; A. M. Fulghesu; Antonio Lanzone; Andrea Morciano; A. Farcomeni; M. F. Gangale; Francesca Moro; Daniela Martinez; A. Ciardulli; C. Palla; M. L. Uras; F. Spettu; A. Cappai; C. Carcassi; Giovanni Neri; Francesco Danilo Tiziano

doi:10.1111/j.1365-2265.2012.04372.x

The 312N variant of the luteinizing hormone/choriogonadotropin receptor gene (LHCGR) confers up to 2·7-fold increased risk of polycystic ovary syndrome in a Sardinian population

Antonio Capalbo
, Francesca Sagnella
, Rosanna Apa
, A. M. Fulghesu
, Antonio Lanzone
, Andrea Morciano
, A. Farcomeni
, M. F. Gangale
, Francesca Moro
, Daniela Martinez
, A. Ciardulli
, C. Palla
, M. L. Uras
, F. Spettu
, A. Cappai
, C. Carcassi
, Giovanni Neri
, Francesco Danilo Tiziano

Research output: Contribution to journal › Article

33 Citations (Scopus)

Abstract

Polycystic ovary syndrome (PCOS) is a frequent condition, affecting about 15% of women of reproductive age. Because of its familial occurrence, a multifactorial model of susceptibility, including both genetic and environmental factors, has been proposed. However, the identification of genetic factors has been elusive.

Original language	English
Pages (from-to)	113-119
Number of pages	7
Journal	Clinical Endocrinology
Volume	77
DOIs	https://doi.org/10.1111/j.1365-2265.2012.04372.x
Publication status	Published - 2012

Keywords

pcos

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10.1111/j.1365-2265.2012.04372.x

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Capalbo, A., Sagnella, F., Apa, R., Fulghesu, A. M., Lanzone, A., Morciano, A., Farcomeni, A., Gangale, M. F., Moro, F., Martinez, D., Ciardulli, A., Palla, C., Uras, M. L., Spettu, F., Cappai, A., Carcassi, C., Neri, G., & Tiziano, F. D. (2012). The 312N variant of the luteinizing hormone/choriogonadotropin receptor gene (LHCGR) confers up to 2·7-fold increased risk of polycystic ovary syndrome in a Sardinian population. Clinical Endocrinology, 77, 113-119. https://doi.org/10.1111/j.1365-2265.2012.04372.x

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title = "The 312N variant of the luteinizing hormone/choriogonadotropin receptor gene (LHCGR) confers up to 2·7-fold increased risk of polycystic ovary syndrome in a Sardinian population",

abstract = "Polycystic ovary syndrome (PCOS) is a frequent condition, affecting about 15\% of women of reproductive age. Because of its familial occurrence, a multifactorial model of susceptibility, including both genetic and environmental factors, has been proposed. However, the identification of genetic factors has been elusive.",

keywords = "pcos, pcos",

author = "Antonio Capalbo and Francesca Sagnella and Rosanna Apa and Fulghesu, \{A. M.\} and Antonio Lanzone and Andrea Morciano and A. Farcomeni and Gangale, \{M. F.\} and Francesca Moro and Daniela Martinez and A. Ciardulli and C. Palla and Uras, \{M. L.\} and F. Spettu and A. Cappai and C. Carcassi and Giovanni Neri and Tiziano, \{Francesco Danilo\}",

year = "2012",

doi = "10.1111/j.1365-2265.2012.04372.x",

language = "English",

volume = "77",

pages = "113--119",

journal = "Clinical Endocrinology",

issn = "1365-2265",

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}

Capalbo, A, Sagnella, F, Apa, R, Fulghesu, AM, Lanzone, A, Morciano, A, Farcomeni, A, Gangale, MF, Moro, F, Martinez, D, Ciardulli, A, Palla, C, Uras, ML, Spettu, F, Cappai, A, Carcassi, C, Neri, G & Tiziano, FD 2012, 'The 312N variant of the luteinizing hormone/choriogonadotropin receptor gene (LHCGR) confers up to 2·7-fold increased risk of polycystic ovary syndrome in a Sardinian population', Clinical Endocrinology, vol. 77, pp. 113-119. https://doi.org/10.1111/j.1365-2265.2012.04372.x

TY - JOUR

T1 - The 312N variant of the luteinizing hormone/choriogonadotropin receptor gene (LHCGR) confers up to 2·7-fold increased risk of polycystic ovary syndrome in a Sardinian population

AU - Capalbo, Antonio

AU - Sagnella, Francesca

AU - Apa, Rosanna

AU - Fulghesu, A. M.

AU - Lanzone, Antonio

AU - Morciano, Andrea

AU - Farcomeni, A.

AU - Gangale, M. F.

AU - Moro, Francesca

AU - Martinez, Daniela

AU - Ciardulli, A.

AU - Palla, C.

AU - Uras, M. L.

AU - Spettu, F.

AU - Cappai, A.

AU - Carcassi, C.

AU - Neri, Giovanni

AU - Tiziano, Francesco Danilo

PY - 2012

Y1 - 2012

N2 - Polycystic ovary syndrome (PCOS) is a frequent condition, affecting about 15% of women of reproductive age. Because of its familial occurrence, a multifactorial model of susceptibility, including both genetic and environmental factors, has been proposed. However, the identification of genetic factors has been elusive.

AB - Polycystic ovary syndrome (PCOS) is a frequent condition, affecting about 15% of women of reproductive age. Because of its familial occurrence, a multifactorial model of susceptibility, including both genetic and environmental factors, has been proposed. However, the identification of genetic factors has been elusive.

KW - pcos

UR - http://hdl.handle.net/10807/6194

U2 - 10.1111/j.1365-2265.2012.04372.x

DO - 10.1111/j.1365-2265.2012.04372.x

M3 - Article

SN - 1365-2265

VL - 77

SP - 113

EP - 119

JO - Clinical Endocrinology

JF - Clinical Endocrinology

ER -

The 312N variant of the luteinizing hormone/choriogonadotropin receptor gene (LHCGR) confers up to 2·7-fold increased risk of polycystic ovary syndrome in a Sardinian population

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Keywords

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