The 312N variant of the luteinizing hormone/choriogonadotropin receptor gene (LHCGR) confers up to 2·7-fold increased risk of polycystic ovary syndrome in a Sardinian population

Antonio Capalbo; Francesca Sagnella; Rosanna Apa; A. M. Fulghesu; Antonio Lanzone; Andrea Morciano; A. Farcomeni; M. F. Gangale; Francesca Moro; Daniela Martinez; A. Ciardulli; C. Palla; M. L. Uras; F. Spettu; A. Cappai; C. Carcassi; Giovanni Neri; Francesco Danilo Tiziano

doi:10.1111/j.1365-2265.2012.04372.x

The 312N variant of the luteinizing hormone/choriogonadotropin receptor gene (LHCGR) confers up to 2·7-fold increased risk of polycystic ovary syndrome in a Sardinian population

Antonio Capalbo, Francesca Sagnella, Rosanna Apa, A. M. Fulghesu, Antonio Lanzone, Andrea Morciano, A. Farcomeni, M. F. Gangale, Francesca Moro, Daniela Martinez, A. Ciardulli, C. Palla, M. L. Uras, F. Spettu, A. Cappai, C. Carcassi, Giovanni Neri, Francesco Danilo Tiziano

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Abstract

Polycystic ovary syndrome (PCOS) is a frequent condition, affecting about 15% of women of reproductive age. Because of its familial occurrence, a multifactorial model of susceptibility, including both genetic and environmental factors, has been proposed. However, the identification of genetic factors has been elusive.

Original language	English
Pages (from-to)	113-119
Number of pages	7
Journal	Clinical Endocrinology
Volume	77
DOIs	https://doi.org/10.1111/j.1365-2265.2012.04372.x
Publication status	Published - 2012

Keywords

pcos

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10.1111/j.1365-2265.2012.04372.x

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Capalbo, A., Sagnella, F., Apa, R., Fulghesu, A. M., Lanzone, A., Morciano, A., Farcomeni, A., Gangale, M. F., Moro, F., Martinez, D., Ciardulli, A., Palla, C., Uras, M. L., Spettu, F., Cappai, A., Carcassi, C., Neri, G., & Tiziano, F. D. (2012). The 312N variant of the luteinizing hormone/choriogonadotropin receptor gene (LHCGR) confers up to 2·7-fold increased risk of polycystic ovary syndrome in a Sardinian population. Clinical Endocrinology, 77, 113-119. https://doi.org/10.1111/j.1365-2265.2012.04372.x

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title = "The 312N variant of the luteinizing hormone/choriogonadotropin receptor gene (LHCGR) confers up to 2·7-fold increased risk of polycystic ovary syndrome in a Sardinian population",

abstract = "Polycystic ovary syndrome (PCOS) is a frequent condition, affecting about 15% of women of reproductive age. Because of its familial occurrence, a multifactorial model of susceptibility, including both genetic and environmental factors, has been proposed. However, the identification of genetic factors has been elusive.",

keywords = "pcos, pcos",

author = "Antonio Capalbo and Francesca Sagnella and Rosanna Apa and Fulghesu, {A. M.} and Antonio Lanzone and Andrea Morciano and A. Farcomeni and Gangale, {M. F.} and Francesca Moro and Daniela Martinez and A. Ciardulli and C. Palla and Uras, {M. L.} and F. Spettu and A. Cappai and C. Carcassi and Giovanni Neri and Tiziano, {Francesco Danilo}",

year = "2012",

doi = "10.1111/j.1365-2265.2012.04372.x",

language = "English",

volume = "77",

pages = "113--119",

journal = "Clinical Endocrinology",

issn = "1365-2265",

publisher = "Wiley-Blackwell Publishing Ltd",

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Capalbo, A, Sagnella, F, Apa, R, Fulghesu, AM, Lanzone, A, Morciano, A, Farcomeni, A, Gangale, MF, Moro, F, Martinez, D, Ciardulli, A, Palla, C, Uras, ML, Spettu, F, Cappai, A, Carcassi, C, Neri, G & Tiziano, FD 2012, 'The 312N variant of the luteinizing hormone/choriogonadotropin receptor gene (LHCGR) confers up to 2·7-fold increased risk of polycystic ovary syndrome in a Sardinian population', Clinical Endocrinology, vol. 77, pp. 113-119. https://doi.org/10.1111/j.1365-2265.2012.04372.x

TY - JOUR

T1 - The 312N variant of the luteinizing hormone/choriogonadotropin receptor gene (LHCGR) confers up to 2·7-fold increased risk of polycystic ovary syndrome in a Sardinian population

AU - Capalbo, Antonio

AU - Sagnella, Francesca

AU - Apa, Rosanna

AU - Fulghesu, A. M.

AU - Lanzone, Antonio

AU - Morciano, Andrea

AU - Farcomeni, A.

AU - Gangale, M. F.

AU - Moro, Francesca

AU - Martinez, Daniela

AU - Ciardulli, A.

AU - Palla, C.

AU - Uras, M. L.

AU - Spettu, F.

AU - Cappai, A.

AU - Carcassi, C.

AU - Neri, Giovanni

AU - Tiziano, Francesco Danilo

PY - 2012

Y1 - 2012

N2 - Polycystic ovary syndrome (PCOS) is a frequent condition, affecting about 15% of women of reproductive age. Because of its familial occurrence, a multifactorial model of susceptibility, including both genetic and environmental factors, has been proposed. However, the identification of genetic factors has been elusive.

AB - Polycystic ovary syndrome (PCOS) is a frequent condition, affecting about 15% of women of reproductive age. Because of its familial occurrence, a multifactorial model of susceptibility, including both genetic and environmental factors, has been proposed. However, the identification of genetic factors has been elusive.

KW - pcos

UR - http://hdl.handle.net/10807/6194

U2 - 10.1111/j.1365-2265.2012.04372.x

DO - 10.1111/j.1365-2265.2012.04372.x

M3 - Article

SN - 1365-2265

VL - 77

SP - 113

EP - 119

JO - Clinical Endocrinology

JF - Clinical Endocrinology

ER -

The 312N variant of the luteinizing hormone/choriogonadotropin receptor gene (LHCGR) confers up to 2·7-fold increased risk of polycystic ovary syndrome in a Sardinian population

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Keywords

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