@article{dc31fbb99b4a4d29b5a9e2df433f46ae,
title = "Glucagon-like peptide-1 receptor activation stimulates hepatic lipid oxidation and restores hepatic signalling alteration induced by a high-fat diet in nonalcoholic steatohepatitis",
abstract = "High-fat dietary intake and low physical activity lead to insulin resistance, nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). Recent studies have shown an effect of glucagon-like peptide-1 (GLP-1) on hepatic glucose metabolism, although GLP-1 receptors (GLP-1r) have not been found in human livers. The aim of this study was to investigate the presence of hepatic GLP-1r and the effect of exenatide, a GLP-1 analogue, on hepatic signalling.",
keywords = "AMP-Activated Protein Kinases, Animals, Biopsy, Cyclic AMP-Dependent Protein Kinases, Dietary Fats, Disease Models, Animal, Fatty Acids, Fatty Liver, Gene Expression Regulation, Hep G2 Cells, Hepatocytes, Humans, Hypoglycemic Agents, Insulin Resistance, JNK Mitogen-Activated Protein Kinases, Liver, Male, Oxidation-Reduction, PPAR alpha, PPAR gamma, Peptides, Phosphorylation, Proto-Oncogene Proteins c-akt, Rats, Rats, Sprague-Dawley, Receptors, Glucagon, Signal Transduction, Time Factors, Venoms, AMP-Activated Protein Kinases, Animals, Biopsy, Cyclic AMP-Dependent Protein Kinases, Dietary Fats, Disease Models, Animal, Fatty Acids, Fatty Liver, Gene Expression Regulation, Hep G2 Cells, Hepatocytes, Humans, Hypoglycemic Agents, Insulin Resistance, JNK Mitogen-Activated Protein Kinases, Liver, Male, Oxidation-Reduction, PPAR alpha, PPAR gamma, Peptides, Phosphorylation, Proto-Oncogene Proteins c-akt, Rats, Rats, Sprague-Dawley, Receptors, Glucagon, Signal Transduction, Time Factors, Venoms",
author = "Gianluca Svegliati-Baroni and Stefania Saccomanno and Sabina Saccomanno and Chiara Rychlicki and Laura Agostinelli and {De Minicis}, Samuele and Cinzia Candelaresi and Graziella Faraci and Deborah Pacetti and Marco Vivarelli and Daniele Nicolini and Paolo Garelli and Alessandro Casini and Melania Manco and Geltrude Mingrone and Andrea Risaliti and Frega, {Giuseppe N.} and Antonio Benedetti and Amalia Gastaldelli",
year = "2011",
doi = "10.1111/j.1478-3231.2011.02462.x",
language = "English",
volume = "31",
pages = "1285--1297",
journal = "Liver International",
issn = "1478-3223",
publisher = "-MALDEN, USA: WILEY-BLACKWELL PUBLISHING -Copenhagen K Denmark: Blackwell Munksgaard",
}
