Testicular FasL is expressed by sperm cells

Alessio D'Alessio; A Riccioli; P Lauretti; F Padula; B Muciaccia; P De Cesaris; A Filippini; S Nagata; E. Ziparo

doi:10.1073/pnas.051566098

Testicular FasL is expressed by sperm cells

Alessio D'Alessio
, A Riccioli
, P Lauretti
, F Padula
, B Muciaccia
, P De Cesaris
, A Filippini
, S Nagata
, E. Ziparo

Research output: Contribution to journal › Article

117 Citations (Scopus)

Abstract

The testis is the main source of Fas ligand (FasL) mRNA in rodents; it is generally believed that this molecule, expressed on bordering somatic Sertoli cells, bestows an immune-privileged status in the testis by eliminating infiltrating inflammatory Fas-bearing leukocytes. Our results demonstrate that the attribution of testicular expression of FasL to Sertoli cells is erroneous and that FasL transcription instead occurs in meiotic and postmeiotic germ cells, whereas the protein is only displayed on mature spermatozoa. These findings point to a significant role of the Fas system in the biology of mammalian reproduction.

Original language	English
Pages (from-to)	3316-3321
Number of pages	6
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	98
DOIs	https://doi.org/10.1073/pnas.051566098
Publication status	Published - 2001

Keywords

Animals
Cells, Cultured
Fas Ligand Protein
Gene Expression
Male
Membrane Glycoproteins
Mice
Rats
Rats, Wistar
Sertoli Cells
Spermatozoa
Testis

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10.1073/pnas.051566098

Cite this

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title = "Testicular FasL is expressed by sperm cells",

abstract = "The testis is the main source of Fas ligand (FasL) mRNA in rodents; it is generally believed that this molecule, expressed on bordering somatic Sertoli cells, bestows an immune-privileged status in the testis by eliminating infiltrating inflammatory Fas-bearing leukocytes. Our results demonstrate that the attribution of testicular expression of FasL to Sertoli cells is erroneous and that FasL transcription instead occurs in meiotic and postmeiotic germ cells, whereas the protein is only displayed on mature spermatozoa. These findings point to a significant role of the Fas system in the biology of mammalian reproduction.",

keywords = "Animals, Cells, Cultured, Fas Ligand Protein, Gene Expression, Male, Membrane Glycoproteins, Mice, Rats, Rats, Wistar, Sertoli Cells, Spermatozoa, Testis, Animals, Cells, Cultured, Fas Ligand Protein, Gene Expression, Male, Membrane Glycoproteins, Mice, Rats, Rats, Wistar, Sertoli Cells, Spermatozoa, Testis",

author = "Alessio D'Alessio and A Riccioli and P Lauretti and F Padula and B Muciaccia and \{De Cesaris\}, P and A Filippini and S Nagata and E. Ziparo",

year = "2001",

doi = "10.1073/pnas.051566098",

language = "English",

volume = "98",

pages = "3316--3321",

journal = "Proceedings of the National Academy of Sciences of the United States of America",

issn = "0027-8424",

publisher = "National Academy of Sciences",

}

TY - JOUR

T1 - Testicular FasL is expressed by sperm cells

AU - D'Alessio, Alessio

AU - Riccioli, A

AU - Lauretti, P

AU - Padula, F

AU - Muciaccia, B

AU - De Cesaris, P

AU - Filippini, A

AU - Nagata, S

AU - Ziparo, E.

PY - 2001

Y1 - 2001

N2 - The testis is the main source of Fas ligand (FasL) mRNA in rodents; it is generally believed that this molecule, expressed on bordering somatic Sertoli cells, bestows an immune-privileged status in the testis by eliminating infiltrating inflammatory Fas-bearing leukocytes. Our results demonstrate that the attribution of testicular expression of FasL to Sertoli cells is erroneous and that FasL transcription instead occurs in meiotic and postmeiotic germ cells, whereas the protein is only displayed on mature spermatozoa. These findings point to a significant role of the Fas system in the biology of mammalian reproduction.

AB - The testis is the main source of Fas ligand (FasL) mRNA in rodents; it is generally believed that this molecule, expressed on bordering somatic Sertoli cells, bestows an immune-privileged status in the testis by eliminating infiltrating inflammatory Fas-bearing leukocytes. Our results demonstrate that the attribution of testicular expression of FasL to Sertoli cells is erroneous and that FasL transcription instead occurs in meiotic and postmeiotic germ cells, whereas the protein is only displayed on mature spermatozoa. These findings point to a significant role of the Fas system in the biology of mammalian reproduction.

KW - Animals

KW - Cells, Cultured

KW - Fas Ligand Protein

KW - Gene Expression

KW - Male

KW - Membrane Glycoproteins

KW - Mice

KW - Rats

KW - Rats, Wistar

KW - Sertoli Cells

KW - Spermatozoa

KW - Testis

KW - Animals

KW - Cells, Cultured

KW - Fas Ligand Protein

KW - Gene Expression

KW - Male

KW - Membrane Glycoproteins

KW - Mice

KW - Rats

KW - Rats, Wistar

KW - Sertoli Cells

KW - Spermatozoa

KW - Testis

UR - http://hdl.handle.net/10807/2785

U2 - 10.1073/pnas.051566098

DO - 10.1073/pnas.051566098

M3 - Article

SN - 0027-8424

VL - 98

SP - 3316

EP - 3321

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

ER -

Testicular FasL is expressed by sperm cells

Abstract

Keywords

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