Targeting prolyl-isomerase Pin1 prevents mitochondrial oxidative stress and vascular dysfunction: insights in patients with diabetes

Francesco Paneni; Sarah Costantino; Lorenzo Castello; Rodolfo Battista; Giuliana Capretti; Sergio Chiandotto; Domenico D'Amario; Giuseppe Scavone; Angelo Villano; Alessandra Rustighi; Filippo Crea; Dario Pitocco; Gaetano Antonio Lanza; Massimo Volpe; Giannino Del Sal; Thomas F. Lüscher; Francesco Cosentino

doi:10.1093/eurheartj/ehu179

Targeting prolyl-isomerase Pin1 prevents mitochondrial oxidative stress and vascular dysfunction: insights in patients with diabetes

Francesco Paneni, Sarah Costantino, Lorenzo Castello, Rodolfo Battista, Giuliana Capretti, Sergio Chiandotto, Domenico D'Amario, Giuseppe Scavone, Angelo Villano, Alessandra Rustighi, Filippo Crea, Dario Pitocco, Gaetano Antonio Lanza, Massimo Volpe, Giannino Del Sal, Thomas F. Lüscher, Francesco Cosentino

Research output: Contribution to journal › Article

53 Citations (Scopus)

Abstract

Diabetes is a major driver of cardiovascular disease, but the underlying mechanisms remain elusive. Prolyl-isomerase Pin1 recognizes specific peptide bonds and modulates function of proteins altering cellular homoeostasis. The present study investigates Pin1 role in diabetes-induced vascular disease.

Original language	English
Pages (from-to)	817-828
Number of pages	12
Journal	European Heart Journal
Volume	36
DOIs	https://doi.org/10.1093/eurheartj/ehu179
Publication status	Published - 2015

Keywords

Diabetes mellitus
Endothelial function
Inflammation
Oxidative stress

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/eurheartj/ehu179

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Paneni, F., Costantino, S., Castello, L., Battista, R., Capretti, G., Chiandotto, S., D'Amario, D., Scavone, G., Villano, A., Rustighi, A., Crea, F., Pitocco, D., Lanza, G. A., Volpe, M., Del Sal, G., Lüscher, T. F., & Cosentino, F. (2015). Targeting prolyl-isomerase Pin1 prevents mitochondrial oxidative stress and vascular dysfunction: insights in patients with diabetes. European Heart Journal, 36, 817-828. https://doi.org/10.1093/eurheartj/ehu179

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title = "Targeting prolyl-isomerase Pin1 prevents mitochondrial oxidative stress and vascular dysfunction: insights in patients with diabetes",

abstract = "Diabetes is a major driver of cardiovascular disease, but the underlying mechanisms remain elusive. Prolyl-isomerase Pin1 recognizes specific peptide bonds and modulates function of proteins altering cellular homoeostasis. The present study investigates Pin1 role in diabetes-induced vascular disease.",

keywords = "Diabetes mellitus, Endothelial function, Inflammation, Oxidative stress, Diabetes mellitus, Endothelial function, Inflammation, Oxidative stress",

author = "Francesco Paneni and Sarah Costantino and Lorenzo Castello and Rodolfo Battista and Giuliana Capretti and Sergio Chiandotto and Domenico D'Amario and Giuseppe Scavone and Angelo Villano and Alessandra Rustighi and Filippo Crea and Dario Pitocco and Lanza, {Gaetano Antonio} and Massimo Volpe and {Del Sal}, Giannino and L{\"u}scher, {Thomas F.} and Francesco Cosentino",

year = "2015",

doi = "10.1093/eurheartj/ehu179",

language = "English",

volume = "36",

pages = "817--828",

journal = "European Heart Journal",

issn = "0195-668X",

publisher = "Oxford : Oxford University Press United Kingdom: Harcourt Publishers Limitedinternational.com, Fax: 011 44 20 83085876",

}

Paneni, F, Costantino, S, Castello, L, Battista, R, Capretti, G, Chiandotto, S, D'Amario, D, Scavone, G, Villano, A, Rustighi, A, Crea, F, Pitocco, D , Lanza, GA, Volpe, M, Del Sal, G, Lüscher, TF & Cosentino, F 2015, 'Targeting prolyl-isomerase Pin1 prevents mitochondrial oxidative stress and vascular dysfunction: insights in patients with diabetes', European Heart Journal, vol. 36, pp. 817-828. https://doi.org/10.1093/eurheartj/ehu179

TY - JOUR

T1 - Targeting prolyl-isomerase Pin1 prevents mitochondrial oxidative stress and vascular dysfunction: insights in patients with diabetes

AU - Paneni, Francesco

AU - Costantino, Sarah

AU - Castello, Lorenzo

AU - Battista, Rodolfo

AU - Capretti, Giuliana

AU - Chiandotto, Sergio

AU - D'Amario, Domenico

AU - Scavone, Giuseppe

AU - Villano, Angelo

AU - Rustighi, Alessandra

AU - Crea, Filippo

AU - Pitocco, Dario

AU - Lanza, Gaetano Antonio

AU - Volpe, Massimo

AU - Del Sal, Giannino

AU - Lüscher, Thomas F.

AU - Cosentino, Francesco

PY - 2015

Y1 - 2015

N2 - Diabetes is a major driver of cardiovascular disease, but the underlying mechanisms remain elusive. Prolyl-isomerase Pin1 recognizes specific peptide bonds and modulates function of proteins altering cellular homoeostasis. The present study investigates Pin1 role in diabetes-induced vascular disease.

AB - Diabetes is a major driver of cardiovascular disease, but the underlying mechanisms remain elusive. Prolyl-isomerase Pin1 recognizes specific peptide bonds and modulates function of proteins altering cellular homoeostasis. The present study investigates Pin1 role in diabetes-induced vascular disease.

KW - Diabetes mellitus

KW - Endothelial function

KW - Inflammation

KW - Oxidative stress

KW - Diabetes mellitus

KW - Endothelial function

KW - Inflammation

KW - Oxidative stress

UR - http://hdl.handle.net/10807/69144

U2 - 10.1093/eurheartj/ehu179

DO - 10.1093/eurheartj/ehu179

M3 - Article

SN - 0195-668X

VL - 36

SP - 817

EP - 828

JO - European Heart Journal

JF - European Heart Journal

ER -

Targeting prolyl-isomerase Pin1 prevents mitochondrial oxidative stress and vascular dysfunction: insights in patients with diabetes

Abstract

Keywords

UN SDGs

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