Targeting prolyl-isomerase Pin1 prevents mitochondrial oxidative stress and vascular dysfunction: insights in patients with diabetes

Filippo Crea, Dario Pitocco, Gaetano Antonio Lanza, Domenico D'Amario, Giuseppe Scavone, Angelo Villano, Massimo Volpe, Francesco Paneni, Sarah Costantino, Lorenzo Castello, Rodolfo Battista, Giuliana Capretti, Sergio Chiandotto, Alessandra Rustighi, Giannino Del Sal, Thomas F. Lüscher, Francesco Cosentino

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Diabetes is a major driver of cardiovascular disease, but the underlying mechanisms remain elusive. Prolyl-isomerase Pin1 recognizes specific peptide bonds and modulates function of proteins altering cellular homoeostasis. The present study investigates Pin1 role in diabetes-induced vascular disease.
Original languageEnglish
Pages (from-to)N/A-N/A
JournalEuropean Heart Journal
DOIs
Publication statusPublished - 2014

Keywords

  • Diabetes mellitus
  • Endothelial function
  • Inflammation
  • Oxidative stress

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