Tamoxifen related Uterine Tumor Resembling Ovarian Sex Cord Tumor (UTROSCT): A case report and literature review of this possible association

Diego Segala; Stefano Gobbo; Anna Pesci; Guido Martignoni; Angela Santoro; Giuseppe Angelico; Damiano Arciuolo; Saveria Spadola; Michele Valente; Giovanni Scambia; Gian Franco Zannoni

doi:10.1016/j.prp.2019.01.039

Tamoxifen related Uterine Tumor Resembling Ovarian Sex Cord Tumor (UTROSCT): A case report and literature review of this possible association

Diego Segala
, Stefano Gobbo
, Anna Pesci
, Guido Martignoni
, Angela Santoro
, Giuseppe Angelico
, Damiano Arciuolo
, Saveria Spadola
, Michele Valente
, Giovanni Scambia
, Gian Franco Zannoni^*

^*Corresponding author

University of Verona
Peschiera del Garda
IRCCS Ospedale Sacro Cuore Don Calabria

Research output: Contribution to journal › Article

1 Citation (Scopus)

Abstract

It is well known that a large number of patients treated with Tamoxifen develops endometrial pathologies ranging from benign endometrial polyps and hyperplasia to adenocarcinomas, carcinosarcomas and adenosarcomas. UTROSCT (Uterine Tumor Resembling Ovarian Sex Cord Tumor) is defined as a mesenchymal tumors of the uterine corpus that morphologically resembles ovarian sex cord tumors, without recognizable endometrial stroma. To date only 4 cases have been reported in patients treated with tamoxifen. In this article, we describe an additional case occurring in a 62-years-old patient undergoing 3 years of Tamoxifen therapy for bilateral breast carcinoma. The present work represents a further evidence of the possible association between Tamoxifen therapy and UTROSCT. A comprehensive literature review on this topic is also provided.

Original language	English
Pages (from-to)	1089-1092
Number of pages	7
Journal	Pathology Research and Practice
Volume	215
Issue number	5
DOIs	https://doi.org/10.1016/j.prp.2019.01.039
Publication status	Published - 2019

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Pathology and Forensic Medicine
Cell Biology

Keywords

2734
Breast cancer
Cell Biology
Imunohistochemistry
Tamoxifen
UTROSCT
Uterine tumor resembling ovarian sex cord tumor

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10.1016/j.prp.2019.01.039

Cite this

Segala, D., Gobbo, S., Pesci, A., Martignoni, G., Santoro, A., Angelico, G., Arciuolo, D., Spadola, S., Valente, M., Scambia, G., & Zannoni, G. F. (2019). Tamoxifen related Uterine Tumor Resembling Ovarian Sex Cord Tumor (UTROSCT): A case report and literature review of this possible association. Pathology Research and Practice, 215(5), 1089-1092. https://doi.org/10.1016/j.prp.2019.01.039

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title = "Tamoxifen related Uterine Tumor Resembling Ovarian Sex Cord Tumor (UTROSCT): A case report and literature review of this possible association",

abstract = "It is well known that a large number of patients treated with Tamoxifen develops endometrial pathologies ranging from benign endometrial polyps and hyperplasia to adenocarcinomas, carcinosarcomas and adenosarcomas. UTROSCT (Uterine Tumor Resembling Ovarian Sex Cord Tumor) is defined as a mesenchymal tumors of the uterine corpus that morphologically resembles ovarian sex cord tumors, without recognizable endometrial stroma. To date only 4 cases have been reported in patients treated with tamoxifen. In this article, we describe an additional case occurring in a 62-years-old patient undergoing 3 years of Tamoxifen therapy for bilateral breast carcinoma. The present work represents a further evidence of the possible association between Tamoxifen therapy and UTROSCT. A comprehensive literature review on this topic is also provided.",

keywords = "2734, Breast cancer, Cell Biology, Imunohistochemistry, Tamoxifen, UTROSCT, Uterine tumor resembling ovarian sex cord tumor, 2734, Breast cancer, Cell Biology, Imunohistochemistry, Tamoxifen, UTROSCT, Uterine tumor resembling ovarian sex cord tumor",

author = "Diego Segala and Stefano Gobbo and Anna Pesci and Guido Martignoni and Angela Santoro and Giuseppe Angelico and Damiano Arciuolo and Saveria Spadola and Michele Valente and Giovanni Scambia and Zannoni, \{Gian Franco\}",

year = "2019",

doi = "10.1016/j.prp.2019.01.039",

language = "English",

volume = "215",

pages = "1089--1092",

journal = "Pathology Research and Practice",

issn = "0344-0338",

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Segala, D, Gobbo, S, Pesci, A, Martignoni, G, Santoro, A, Angelico, G, Arciuolo, D, Spadola, S, Valente, M, Scambia, G & Zannoni, GF 2019, 'Tamoxifen related Uterine Tumor Resembling Ovarian Sex Cord Tumor (UTROSCT): A case report and literature review of this possible association', Pathology Research and Practice, vol. 215, no. 5, pp. 1089-1092. https://doi.org/10.1016/j.prp.2019.01.039

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AU - Segala, Diego

AU - Gobbo, Stefano

AU - Pesci, Anna

AU - Martignoni, Guido

AU - Santoro, Angela

AU - Angelico, Giuseppe

AU - Arciuolo, Damiano

AU - Spadola, Saveria

AU - Valente, Michele

AU - Scambia, Giovanni

AU - Zannoni, Gian Franco

PY - 2019

Y1 - 2019

N2 - It is well known that a large number of patients treated with Tamoxifen develops endometrial pathologies ranging from benign endometrial polyps and hyperplasia to adenocarcinomas, carcinosarcomas and adenosarcomas. UTROSCT (Uterine Tumor Resembling Ovarian Sex Cord Tumor) is defined as a mesenchymal tumors of the uterine corpus that morphologically resembles ovarian sex cord tumors, without recognizable endometrial stroma. To date only 4 cases have been reported in patients treated with tamoxifen. In this article, we describe an additional case occurring in a 62-years-old patient undergoing 3 years of Tamoxifen therapy for bilateral breast carcinoma. The present work represents a further evidence of the possible association between Tamoxifen therapy and UTROSCT. A comprehensive literature review on this topic is also provided.

AB - It is well known that a large number of patients treated with Tamoxifen develops endometrial pathologies ranging from benign endometrial polyps and hyperplasia to adenocarcinomas, carcinosarcomas and adenosarcomas. UTROSCT (Uterine Tumor Resembling Ovarian Sex Cord Tumor) is defined as a mesenchymal tumors of the uterine corpus that morphologically resembles ovarian sex cord tumors, without recognizable endometrial stroma. To date only 4 cases have been reported in patients treated with tamoxifen. In this article, we describe an additional case occurring in a 62-years-old patient undergoing 3 years of Tamoxifen therapy for bilateral breast carcinoma. The present work represents a further evidence of the possible association between Tamoxifen therapy and UTROSCT. A comprehensive literature review on this topic is also provided.

KW - 2734

KW - Breast cancer

KW - Cell Biology

KW - Imunohistochemistry

KW - Tamoxifen

KW - UTROSCT

KW - Uterine tumor resembling ovarian sex cord tumor

KW - 2734

KW - Breast cancer

KW - Cell Biology

KW - Imunohistochemistry

KW - Tamoxifen

KW - UTROSCT

KW - Uterine tumor resembling ovarian sex cord tumor

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ER -

Tamoxifen related Uterine Tumor Resembling Ovarian Sex Cord Tumor (UTROSCT): A case report and literature review of this possible association

Abstract

UN SDGs

All Science Journal Classification (ASJC) codes

Keywords

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