Systemic complications of esophageal lichen planus

Simone Garcovich, Raffaele Manna, Maria Giovinale, Alessia Marinaro, Chiara Manganelli, Anna Zampetti, Claudio Feliciani

Research output: Contribution to journalArticle

3 Citations (Scopus)


Lichen planus is an uncommon inflammatory mucocutaneous disorder affecting the skin and its appendages, as well as oral and genital mucosa. Involvement of the esophageal mucosa is rare and causes significant morbidity, with dysphagia and risk of long-term complications, such as esophageal strictures and stenosis. Esophageal lichen planus is an underreported condition in the spectrum of lichenoid tissue reactions, presenting the risk of systemic manifestations. We describe a patient with severe, long-standing esophageal lichen planus, which had led to marked weight-loss, malnutrition syndrome and chronic respiratory distress due to recurrent aspiration pneumonia. Diagnosis was confirmed by the presence of concomitant muco-cutaneous lesions and characteristic endoscopic and histological findings. Systemic therapy with cyclosporine A and micronutrient supplementation led to rapid clinical improvement. Early diagnosis of esophageal lichen planus as well as effective systemic immunosuppressive treatment is crucial in order to prevent short- and long-term complications.
Original languageEnglish
Pages (from-to)575-578
Number of pages4
JournalInternational Journal of Immunopathology and Pharmacology
Publication statusPublished - 2013


  • Biopsy
  • Cyclosporine
  • Dietary Supplements
  • Esophageal Diseases
  • Female
  • Humans
  • Immunosuppressive Agents
  • Lichen Planus
  • Malnutrition
  • Middle Aged
  • Pneumonia, Aspiration
  • Recurrence
  • Treatment Outcome


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