Synthesis of some pyrazole derivatives and preliminary investigation of their affinity binding to P-glycoprotein

F Manna; F Chimenti; R Fioravanti; A Bolasco; D Secci; P Chimenti; Cristiano Ferlini; Giovanni Scambia

Synthesis of some pyrazole derivatives and preliminary investigation of their affinity binding to P-glycoprotein

F Manna, F Chimenti, R Fioravanti, A Bolasco, D Secci, P Chimenti, Cristiano Ferlini, Giovanni Scambia

Research output: Contribution to journal › Article

Abstract

A series of substituted pyrazolines were synthesized and evaluated for their anticancer activity and for their ability to inhibit P-glycoprotein-mediated multidrug resistance by direct binding to a purified protein domain containing an ATP-binding site and a modulator interacting region. Compounds 2a and e have been found to bind to P-glycoprotein with greater affinity

Original language	English
Pages (from-to)	4632-4635
Number of pages	4
Journal	BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Publication status	Published - 2005

Keywords

P-GLYCOPROTEIN
PYRAZOLE DERIVATES

Cite this

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title = "Synthesis of some pyrazole derivatives and preliminary investigation of their affinity binding to P-glycoprotein",

abstract = "A series of substituted pyrazolines were synthesized and evaluated for their anticancer activity and for their ability to inhibit P-glycoprotein-mediated multidrug resistance by direct binding to a purified protein domain containing an ATP-binding site and a modulator interacting region. Compounds 2a and e have been found to bind to P-glycoprotein with greater affinity",

keywords = "P-GLYCOPROTEIN, PYRAZOLE DERIVATES, P-GLYCOPROTEIN, PYRAZOLE DERIVATES",

author = "F Manna and F Chimenti and R Fioravanti and A Bolasco and D Secci and P Chimenti and Cristiano Ferlini and Giovanni Scambia",

year = "2005",

language = "English",

pages = "4632--4635",

journal = "BIOORGANIC \& MEDICINAL CHEMISTRY LETTERS",

issn = "0960-894X",

publisher = "Elsevier Science Limited:Oxford Fulfillment Center, PO Box 800, Kidlington Oxford OX5 1DX United Kingdom:011 44 1865 843000, 011 44 1865 843699, EMAIL: [email protected], [email protected], INTERNET: http://www.elsevier.com, http://www.elsevier.com/locate/shpsa/, Fax: 011 44 1865 843010",

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TY - JOUR

T1 - Synthesis of some pyrazole derivatives and preliminary investigation of their affinity binding to P-glycoprotein

AU - Manna, F

AU - Chimenti, F

AU - Fioravanti, R

AU - Bolasco, A

AU - Secci, D

AU - Chimenti, P

AU - Ferlini, Cristiano

AU - Scambia, Giovanni

PY - 2005

Y1 - 2005

N2 - A series of substituted pyrazolines were synthesized and evaluated for their anticancer activity and for their ability to inhibit P-glycoprotein-mediated multidrug resistance by direct binding to a purified protein domain containing an ATP-binding site and a modulator interacting region. Compounds 2a and e have been found to bind to P-glycoprotein with greater affinity

AB - A series of substituted pyrazolines were synthesized and evaluated for their anticancer activity and for their ability to inhibit P-glycoprotein-mediated multidrug resistance by direct binding to a purified protein domain containing an ATP-binding site and a modulator interacting region. Compounds 2a and e have been found to bind to P-glycoprotein with greater affinity

KW - P-GLYCOPROTEIN

KW - PYRAZOLE DERIVATES

KW - P-GLYCOPROTEIN

KW - PYRAZOLE DERIVATES

UR - http://hdl.handle.net/10807/198371

M3 - Article

SN - 0960-894X

SP - 4632

EP - 4635

JO - BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

JF - BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

ER -

Synthesis of some pyrazole derivatives and preliminary investigation of their affinity binding to P-glycoprotein

Abstract

Keywords

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