Synthesis of Polycyclic Chromene Cores through Gold (I)-Catalyzed Intramolecular Hydroarylation Reaction (IMHA)

Antonio Arcadi, Giancarlo Fabrizi, Andrea Fochetti, Roberta Franzini, Francesca Ghirga, Antonella Goggiamani*, Antonia Iazzetti*, Federico Marrone, Andrea Serraiocco

*Corresponding author

Research output: Contribution to journalArticle

Abstract

A regioselective gold (I)-catalyzed approach for the construction of polycyclic chromene cores has been developed. The reaction proceeds in good to excellent yields under mild condition with a broad range of substrates providing a simple and efficient tool for the synthesis of pyranochromene derivatives. Moreover, the regiochemical control of the annulation of unsymmetrically substituted propargylic ethers has been investigated focusing on electronic/steric effects of the ligands of gold complexes as well as on the electronic effects of the groups on the aromatic rings.
Original languageEnglish
Pages (from-to)1676-1687
Number of pages12
JournalEuropean Journal of Organic Chemistry
Volume2021
DOIs
Publication statusPublished - 2021

Keywords

  • Annulation
  • Gold catalysis
  • Hydroarylation

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