Synthesis of 3-substituted 2,3-dihydropyrazino[1,2- a]indol-4(1H)-ones by sequential reactions of 2- indolylmethyl acetates with a-amino acids

Antonella Goggiamani, Antonio Arcadi, Alessia Ciogli, Martina De Angelis, Stefano Dessalvi, Giancarlo Fabrizi, Federica Iavarone, Antonia Iazzetti, Alessio Sferrazza, Roberta Zoppoli

Research output: Contribution to journalArticle

Abstract

The synthesis of 2,3-dihydropyrazino[1,2-a]indol-4(1H)-ones from the sequential reaction of amino acid methyl esters with readily available indole-2-ylmethyl acetates is described. The reaction proceeds in situ under basic conditions of highly unstable and reactive 2-alkylideneindolenines followed by Michael-type addition of a-amino acid methyl esters/intramolecular cyclization.
Original languageEnglish
Pages (from-to)10090-10096
Number of pages7
JournalRSC Advances
Volume13
DOIs
Publication statusPublished - 2023

Keywords

  • reaction

Fingerprint

Dive into the research topics of 'Synthesis of 3-substituted 2,3-dihydropyrazino[1,2- a]indol-4(1H)-ones by sequential reactions of 2- indolylmethyl acetates with a-amino acids'. Together they form a unique fingerprint.

Cite this