Synergies between assisted reproduction technologies and functional genomics

Pasqualino Loi; Paola Toschi; Federica Zacchini; Grazyna Ptak; Pier A. Scapolo; Emanuele Capra; Alessandra Stella; Paolo Ajmone Marsan; John L. Williams

doi:10.1186/s12711-016-0231-z

Synergies between assisted reproduction technologies and functional genomics

Pasqualino Loi^*
, Paola Toschi
, Federica Zacchini
, Grazyna Ptak
, Pier A. Scapolo
, Emanuele Capra
, Alessandra Stella
, Paolo Ajmone Marsan
, John L. Williams

^*Corresponding author

University of Teramo
Institute of Genetics and Animal Breeding of the Polish Academy of Sciences
National Research Institute of Animal Production, Krakow
Institute for Polymers
University of Adelaide

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

This review, is a synopsis of advanced reproductive technologies in farm animals, including the discussion of their limiting factors as revealed by the study of offspring derived from embryos produced in vitro and through cloning. These studies show that the problems of epigenetic mis-programming, which were reported in the initial stages of assisted reproduction, still persist. The importance of whole-genome analyses, including the methylome and transcriptome, in improving embryo biotechnologies in farm animals, are discussed. Genome editing approaches for the improvement of economically-relevant traits in farm animals are also described. Efficient farm animal embryo biotechnologies, including cloning and the most recent technologies such as genome editing, will effectively complement the latest strategies to accelerate genetic improvement of farm animals.

Original language	English
Pages (from-to)	N/A-N/A
Journal	Genetics Selection Evolution
Volume	48
Issue number	1
DOIs	https://doi.org/10.1186/s12711-016-0231-z
Publication status	Published - 2016

All Science Journal Classification (ASJC) codes

Ecology, Evolution, Behavior and Systematics
Animal Science and Zoology
Genetics

Keywords

Animal Science and Zoology
Behavior and Systematics
Ecology
Evolution
Genetics

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10.1186/s12711-016-0231-z

Cite this

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abstract = "This review, is a synopsis of advanced reproductive technologies in farm animals, including the discussion of their limiting factors as revealed by the study of offspring derived from embryos produced in vitro and through cloning. These studies show that the problems of epigenetic mis-programming, which were reported in the initial stages of assisted reproduction, still persist. The importance of whole-genome analyses, including the methylome and transcriptome, in improving embryo biotechnologies in farm animals, are discussed. Genome editing approaches for the improvement of economically-relevant traits in farm animals are also described. Efficient farm animal embryo biotechnologies, including cloning and the most recent technologies such as genome editing, will effectively complement the latest strategies to accelerate genetic improvement of farm animals.",

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AU - Toschi, Paola

AU - Zacchini, Federica

AU - Ptak, Grazyna

AU - Scapolo, Pier A.

AU - Capra, Emanuele

AU - Stella, Alessandra

AU - Ajmone Marsan, Paolo

AU - Williams, John L.

PY - 2016

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N2 - This review, is a synopsis of advanced reproductive technologies in farm animals, including the discussion of their limiting factors as revealed by the study of offspring derived from embryos produced in vitro and through cloning. These studies show that the problems of epigenetic mis-programming, which were reported in the initial stages of assisted reproduction, still persist. The importance of whole-genome analyses, including the methylome and transcriptome, in improving embryo biotechnologies in farm animals, are discussed. Genome editing approaches for the improvement of economically-relevant traits in farm animals are also described. Efficient farm animal embryo biotechnologies, including cloning and the most recent technologies such as genome editing, will effectively complement the latest strategies to accelerate genetic improvement of farm animals.

AB - This review, is a synopsis of advanced reproductive technologies in farm animals, including the discussion of their limiting factors as revealed by the study of offspring derived from embryos produced in vitro and through cloning. These studies show that the problems of epigenetic mis-programming, which were reported in the initial stages of assisted reproduction, still persist. The importance of whole-genome analyses, including the methylome and transcriptome, in improving embryo biotechnologies in farm animals, are discussed. Genome editing approaches for the improvement of economically-relevant traits in farm animals are also described. Efficient farm animal embryo biotechnologies, including cloning and the most recent technologies such as genome editing, will effectively complement the latest strategies to accelerate genetic improvement of farm animals.

KW - Animal Science and Zoology

KW - Behavior and Systematics

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KW - Evolution

KW - Genetics

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KW - Ecology

KW - Evolution

KW - Genetics

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Synergies between assisted reproduction technologies and functional genomics

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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