TY - JOUR
T1 - Synergies between assisted reproduction technologies and functional genomics
AU - Loi, Pasqualino
AU - Toschi, Paola
AU - Zacchini, Federica
AU - Ptak, Grazyna
AU - Scapolo, Pier A.
AU - Capra, Emanuele
AU - Stella, Alessandra
AU - Ajmone Marsan, Paolo
AU - Williams, John L.
PY - 2016
Y1 - 2016
N2 - This review, is a synopsis of advanced reproductive technologies in farm animals, including the discussion of their limiting factors as revealed by the study of offspring derived from embryos produced in vitro and through cloning. These studies show that the problems of epigenetic mis-programming, which were reported in the initial stages of assisted reproduction, still persist. The importance of whole-genome analyses, including the methylome and transcriptome, in improving embryo biotechnologies in farm animals, are discussed. Genome editing approaches for the improvement of economically-relevant traits in farm animals are also described. Efficient farm animal embryo biotechnologies, including cloning and the most recent technologies such as genome editing, will effectively complement the latest strategies to accelerate genetic improvement of farm animals.
AB - This review, is a synopsis of advanced reproductive technologies in farm animals, including the discussion of their limiting factors as revealed by the study of offspring derived from embryos produced in vitro and through cloning. These studies show that the problems of epigenetic mis-programming, which were reported in the initial stages of assisted reproduction, still persist. The importance of whole-genome analyses, including the methylome and transcriptome, in improving embryo biotechnologies in farm animals, are discussed. Genome editing approaches for the improvement of economically-relevant traits in farm animals are also described. Efficient farm animal embryo biotechnologies, including cloning and the most recent technologies such as genome editing, will effectively complement the latest strategies to accelerate genetic improvement of farm animals.
KW - Animal Science and Zoology
KW - Ecology, Evolution, Behavior and Systematics
KW - Genetics
KW - Animal Science and Zoology
KW - Ecology, Evolution, Behavior and Systematics
KW - Genetics
UR - http://hdl.handle.net/10807/92033
UR - http://www.gsejournal.org/
U2 - 10.1186/s12711-016-0231-z
DO - 10.1186/s12711-016-0231-z
M3 - Article
SN - 0999-193X
VL - 48
SP - N/A-N/A
JO - Genetics Selection Evolution
JF - Genetics Selection Evolution
ER -