Susceptibility to ventricular arrhythmias in aged hearts

Andrea Bertuzzi, Donatella Brisinda, Riccardo Fenici, S Rossi, S Baruffi, F Mastorci, A Sgoifo, E Musso, D Corradi, R Maestri, E. Macchi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Cardiac arrhythmias are frequent in the elderly population, perhaps secondary to an increased prevalence of hypertension and coronary artery disease as well as aging related changes resulting in loss of pacemaker cells and degenerative alteration of the conduction system. Independent from underlying structural heart disease, advanced age alone appears to be a risk factor for increased susceptibility to ventricular arrhythmia. However, the electrophysiological basis of this phenomenon is still unclear. Thus, it is important to assess and to define the underlying arrhythmogenic substrate. The aim of the present study was to identify a likely structural-functional ventricular arrhythmogenic substrate in aged hearts. For this purpose ventricular activation patterns were measured in control (n=4) and aged (n=10) in vivo rat hearts by recording unipolar electrograms with an epicardial, 1 mm resolution, 8x8 electrode array, during pacing and spontaneous or induced ventricular ectopic beats. Our results in aged hearts suggest that peripheral conduction system might be involved in perpetuating sequences of ventricular ectopic beats, regardless of their origin.
Original languageEnglish
Title of host publicationIEEE EMB 2007 Abstract book
Pages300
Number of pages1
Publication statusPublished - 2007
Event29th annual Conference of the IEEE Engineering in Medicini and Biology Society - Lyon
Duration: 1 Jan 2007 → …

Conference

Conference29th annual Conference of the IEEE Engineering in Medicini and Biology Society
CityLyon
Period1/1/07 → …

Keywords

  • Age Factors
  • Animals
  • Arrhythmias, Cardiac
  • Disease Susceptibility
  • Male
  • Rats
  • Ventricular Dysfunction

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