Susceptibility to Ventricular Arrhythmias in Aged Hearts

Andrea Bertuzzi, Donatella Brisinda, Riccardo Fenici, S Rossi, S Baruffi, F Mastorci, A Sgoifo, E Musso, D Corradi, R Maestri, N. Null

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Cardiac arrhythmias are frequent in the elderly population, perhaps secondary to an increased prevalence of hypertension and coronary artery disease as well as aging related changes resulting in loss of pacemaker cells and degenerative alteration of the conduction system. Independent from underlying structural heart disease, advanced age alone appears to be a risk factor for increased susceptibility to ventricular arrhythmia. However, the electrophysiological basis of this phenomenon is still unclear. Thus, it is important to assess and to define the underlying arrhythmogenic substrate. The aim of the present study was to identify a likely structural-functional ventricular arrhythmogenic substrate in aged hearts. For this purpose ventricular activation patterns were measured in control (n = 4) and aged (n = 10) in vivo rat hearts by recording unipolar electrograms with an epicardial, 1 mm resolution, 8 times 8 electrode array, during pacing and spontaneous or induced ventricular ectopic beats. Our results in aged hearts suggest that peripheral conduction system might be involved in perpetuating sequences of ventricular ectopic beats, regardless of their origin
Original languageEnglish
Title of host publicationEngineering in Medicine and Biology Society, 2007. EMBS 2007. 29th Annual International Conference of the IEEE
Pages410-414
Number of pages5
DOIs
Publication statusPublished - 2007
Event29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society - Lyon
Duration: 22 Aug 200726 Aug 2007

Conference

Conference29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
CityLyon
Period22/8/0726/8/07

Keywords

  • Ageing
  • Cardiac pacing
  • Epicardial mapping
  • Experimental electrophysiology
  • Ventricular arrhythmias

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