Susceptibility Testing of Common and Uncommon Aspergillus Species Against Posaconazole and Other Mold-Active Antifungal Azoles Using the Sensititre Method

Enrica Mello; Brunella Posteraro; Antonietta Vella; Elena De Carolis; Riccardo Torelli; Tiziana D'Inzeo; Paul E. Verweij; Maurizio Sanguinetti

doi:10.1128/AAC.00168-17

Susceptibility Testing of Common and Uncommon Aspergillus Species Against Posaconazole and Other Mold-Active Antifungal Azoles Using the Sensititre Method

Enrica Mello, Brunella Posteraro, Antonietta Vella, Elena De Carolis, Riccardo Torelli, Tiziana D'Inzeo, Paul E. Verweij, Maurizio Sanguinetti

Radboud University Nijmegen

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18 Citations (Scopus)

Abstract

We tested 59 common and 27 uncommon Aspergillus species isolates for the susceptibility to the mold-active azole antifungal agents, itraconazole, voriconazole, and posaconazole, using the Sensititre method. The overall essential agreement with the CLSI reference method was 96.5% for itraconazole and posaconazole, and 100% for voriconazole. By Sensititre, as well as CLSI, all of 10 A. fumigatus isolates with a cyp51 mutant genotype were classified as being non-wild-type (MIC > ECV) to triazoles.

Original language	English
Pages (from-to)	00168-17-N/A
Journal	Antimicrobial Agents and Chemotherapy
Volume	61
DOIs	https://doi.org/10.1128/AAC.00168-17
Publication status	Published - 2017

Keywords

Aspergillus

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10.1128/AAC.00168-17

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Mello, E., Posteraro, B., Vella, A., De Carolis, E., Torelli, R., D'Inzeo, T., Verweij, P. E., & Sanguinetti, M. (2017). Susceptibility Testing of Common and Uncommon Aspergillus Species Against Posaconazole and Other Mold-Active Antifungal Azoles Using the Sensititre Method. Antimicrobial Agents and Chemotherapy, 61, 00168-17-N/A. https://doi.org/10.1128/AAC.00168-17

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abstract = "We tested 59 common and 27 uncommon Aspergillus species isolates for the susceptibility to the mold-active azole antifungal agents, itraconazole, voriconazole, and posaconazole, using the Sensititre method. The overall essential agreement with the CLSI reference method was 96.5% for itraconazole and posaconazole, and 100% for voriconazole. By Sensititre, as well as CLSI, all of 10 A. fumigatus isolates with a cyp51 mutant genotype were classified as being non-wild-type (MIC > ECV) to triazoles.",

keywords = "Aspergillus, Aspergillus",

author = "Enrica Mello and Brunella Posteraro and Antonietta Vella and {De Carolis}, Elena and Riccardo Torelli and Tiziana D'Inzeo and Verweij, {Paul E.} and Maurizio Sanguinetti",

year = "2017",

doi = "10.1128/AAC.00168-17",

language = "English",

volume = "61",

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T1 - Susceptibility Testing of Common and Uncommon Aspergillus Species Against Posaconazole and Other Mold-Active Antifungal Azoles Using the Sensititre Method

AU - Mello, Enrica

AU - Posteraro, Brunella

AU - Vella, Antonietta

AU - De Carolis, Elena

AU - Torelli, Riccardo

AU - D'Inzeo, Tiziana

AU - Verweij, Paul E.

AU - Sanguinetti, Maurizio

PY - 2017

Y1 - 2017

N2 - We tested 59 common and 27 uncommon Aspergillus species isolates for the susceptibility to the mold-active azole antifungal agents, itraconazole, voriconazole, and posaconazole, using the Sensititre method. The overall essential agreement with the CLSI reference method was 96.5% for itraconazole and posaconazole, and 100% for voriconazole. By Sensititre, as well as CLSI, all of 10 A. fumigatus isolates with a cyp51 mutant genotype were classified as being non-wild-type (MIC > ECV) to triazoles.

AB - We tested 59 common and 27 uncommon Aspergillus species isolates for the susceptibility to the mold-active azole antifungal agents, itraconazole, voriconazole, and posaconazole, using the Sensititre method. The overall essential agreement with the CLSI reference method was 96.5% for itraconazole and posaconazole, and 100% for voriconazole. By Sensititre, as well as CLSI, all of 10 A. fumigatus isolates with a cyp51 mutant genotype were classified as being non-wild-type (MIC > ECV) to triazoles.

KW - Aspergillus

UR - http://hdl.handle.net/10807/98185

U2 - 10.1128/AAC.00168-17

DO - 10.1128/AAC.00168-17

M3 - Article

SN - 0066-4804

VL - 61

SP - 00168-17-N/A

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

ER -

Susceptibility Testing of Common and Uncommon Aspergillus Species Against Posaconazole and Other Mold-Active Antifungal Azoles Using the Sensititre Method

Abstract

Keywords

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