Susceptibility Testing of Common and Uncommon Aspergillus Species Against Posaconazole and Other Mold-Active Antifungal Azoles Using the Sensititre Method

Brunella Posteraro, Tiziana D'Inzeo, Maurizio Sanguinetti, Antonietta Vella, Elena De Carolis, Riccardo Torelli, Paul E. Verweij

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

We tested 59 common and 27 uncommon Aspergillus species isolates for the susceptibility to the mold-active azole antifungal agents, itraconazole, voriconazole, and posaconazole, using the Sensititre method. The overall essential agreement with the CLSI reference method was 96.5% for itraconazole and posaconazole, and 100% for voriconazole. By Sensititre, as well as CLSI, all of 10 A. fumigatus isolates with a cyp51 mutant genotype were classified as being non-wild-type (MIC > ECV) to triazoles.
Original languageEnglish
Pages (from-to)00168-17-N/A
JournalAntimicrobial Agents and Chemotherapy
Volume61
DOIs
Publication statusPublished - 2017

Keywords

  • Aspergillus

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