Superinfection with drug-resistant HIV is rare and does not contribute substantially to therapy failure in a large European cohort

István Bartha, Matthias Assel, Peter M.A. Sloot, Maurizio Zazzi, Carlo Torti, Eugen Schülter, Andrea De Luca, Anders Sönnerborg, Ana B. Abecasis, Kristel Van Laethem, Andrea Rosi, Jenny Svärd, Roger Paredes, David A.M.C. Van De Vijver, Anne-Mieke Vandamme, Viktor Müller

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Superinfection with drug resistant HIV strains could potentially contribute to compromised therapy in patients initially infected with drug-sensitive virus and receiving antiretroviral therapy. To investigate the importance of this potential route to drug resistance, we developed a bioinformatics pipeline to detect superinfection from routinely collected genotyping data, and assessed whether superinfection contributed to increased drug resistance in a large European cohort of viremic, drug treated patients.
Original languageEnglish
Pages (from-to)537-537
Number of pages1
JournalBMC Infectious Diseases
Volume13
DOIs
Publication statusPublished - 2013

Keywords

  • antiretroviral therapy
  • drug resistant
  • hiv
  • resistance

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