Sulodexide alone or in combination with low doses of everolimus inhibits the hypoxia-mediated epithelial to mesenchymal transition in human renal proximal tubular cells

Giovanni Gambaro, Gianluigi Zaza, Valentina Masola, Simona Granata, Gloria Bellin, Alessandra Dalla Gassa, Maurizio Onisto, Antonio Lupo

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

Prolonged cold ischemia time, the period from the start of perfusion with cold preservation fluid after cessation of circulation due to arterial clamping until transplantation in the recipient, could induce epithelial-to-mesenchymal transition (EMT) in renal tubular cells, a process associated with chronic graft damage. In this context, everolimus (EVE) and sulodexide (SUL) could potentially slow down this process.
Original languageEnglish
Pages (from-to)431-440
Number of pages10
JournalJN. JOURNAL OF NEPHROLOGY
Volume28
DOIs
Publication statusPublished - 2015

Keywords

  • everolimus

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