Subarachnoid hemorrhage during sexual activity after sildenafil intake: an accidental association?

Fabio De Giorgio, Vincenzo Arena, Elisa Arena, Maria Lodise, Ernesto D'Aloja, Marcello Chiarotti, Luca Valerio

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

We report and describe an autopsy case of a man dead for rupture of cerebral artery aneurysm with subsequent subarachnoid hemorrhage after sexual intercourse. Toxicologic analysis demonstrated that he had consumed sildenafil (Viagra). Although subarachnoid hemorrhage has been reported to be associated with sexual intercourse, it is not among the known adverse effects of sildenafil. However, sildenafil has been found to interact with vascular physiology via multiple mechanisms and in most of the vascular districts of the human body. This case provides an example of a very rare association between this drug and a fatal pathologic event and deserves to be added to the existing clinical knowledge about sildenafil and the pathophysiology of the events involved. This knowledge may be helpful in orienting further investigation into the mechanisms of action of sildenafil and their clinical implications.
Original languageEnglish
Pages (from-to)310-311
Number of pages2
JournalTHE AMERICAN JOURNAL OF FORENSIC MEDICINE AND PATHOLOGY
Volume2011
Publication statusPublished - 2011

Keywords

  • sildenafil
  • subarachnoid hemorrhage

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