Stereotyped B-cell receptor is an independent risk factor of chronic lymphocytic leukemia transformation to Richter syndrome

Davide Rossi; Valeria Spina; Michaela Cerri; Silvia Rasi; Clara Deambrogi; Lorenzo De Paoli; Luca Laurenti; Rossana Maffei; Francesco Forconi; Francesco Bertoni; Emanuele Zucca; Claudio Agostinelli; Antonello Cabras; Marco Lucioni; Maurizio Martini; Michele Magni; Silvia Deaglio; Marco Ladetto; Joseph F. Nomdedeu; Caroline Besson; Antonio Ramponi; Vincenzo Canzonieri; Marco Paulli; Roberto Marasca; Luigi Maria Larocca; Antonino Carbone; Stefano A. Pileri; Valter Gattei; Gianluca Gaidano

doi:10.1158/1078-0432.CCR-08-3266

Stereotyped B-cell receptor is an independent risk factor of chronic lymphocytic leukemia transformation to Richter syndrome

Davide Rossi
, Valeria Spina
, Michaela Cerri
, Silvia Rasi
, Clara Deambrogi
, Lorenzo De Paoli
, Luca Laurenti
, Rossana Maffei
, Francesco Forconi
, Francesco Bertoni
, Emanuele Zucca
, Claudio Agostinelli
, Antonello Cabras
, Marco Lucioni
, Maurizio Martini
, Michele Magni
, Silvia Deaglio
, Marco Ladetto
, Joseph F. Nomdedeu
, Caroline Besson

Antonio Ramponi, Vincenzo Canzonieri, Marco Paulli, Roberto Marasca, Luigi Maria Larocca, Antonino Carbone, Stefano A. Pileri, Valter Gattei, Gianluca Gaidano

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130 Citations (Scopus)

Abstract

Few biological prognosticators are useful for prediction of Richter syndrome (RS), representing the transformation of chronic lymphocytic leukemia (CLL) to aggressive lymphoma. Stereotyped B-cell receptors (BCR) may have prognostic effect in CLL progression. We tested the prognostic effect of stereotyped BCR for predicting RS transformation.

Original language	English
Pages (from-to)	4415-4422
Number of pages	8
Journal	Clinical Cancer Research
Volume	15
DOIs	https://doi.org/10.1158/1078-0432.CCR-08-3266
Publication status	Published - 2009

Keywords

Aged
Cohort Studies
Disease Progression
Female
Gene Frequency
Genetic Predisposition to Disease
Humans
Leukemia, Lymphocytic, Chronic, B-Cell
Lymphoma
Male
Middle Aged
Neoplasm Invasiveness
Polymorphism, Genetic
Proto-Oncogene Proteins c-bcr
Risk Factors
Syndrome

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10.1158/1078-0432.CCR-08-3266

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Rossi, D., Spina, V., Cerri, M., Rasi, S., Deambrogi, C., De Paoli, L., Laurenti, L., Maffei, R., Forconi, F., Bertoni, F., Zucca, E., Agostinelli, C., Cabras, A., Lucioni, M., Martini, M., Magni, M., Deaglio, S., Ladetto, M., Nomdedeu, J. F., ... Gaidano, G. (2009). Stereotyped B-cell receptor is an independent risk factor of chronic lymphocytic leukemia transformation to Richter syndrome. Clinical Cancer Research, 15, 4415-4422. https://doi.org/10.1158/1078-0432.CCR-08-3266

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title = "Stereotyped B-cell receptor is an independent risk factor of chronic lymphocytic leukemia transformation to Richter syndrome",

abstract = "Few biological prognosticators are useful for prediction of Richter syndrome (RS), representing the transformation of chronic lymphocytic leukemia (CLL) to aggressive lymphoma. Stereotyped B-cell receptors (BCR) may have prognostic effect in CLL progression. We tested the prognostic effect of stereotyped BCR for predicting RS transformation.",

keywords = "Aged, Cohort Studies, Disease Progression, Female, Gene Frequency, Genetic Predisposition to Disease, Humans, Leukemia, Lymphocytic, Chronic, B-Cell, Lymphoma, Male, Middle Aged, Neoplasm Invasiveness, Polymorphism, Genetic, Proto-Oncogene Proteins c-bcr, Risk Factors, Syndrome, Aged, Cohort Studies, Disease Progression, Female, Gene Frequency, Genetic Predisposition to Disease, Humans, Leukemia, Lymphocytic, Chronic, B-Cell, Lymphoma, Male, Middle Aged, Neoplasm Invasiveness, Polymorphism, Genetic, Proto-Oncogene Proteins c-bcr, Risk Factors, Syndrome",

author = "Davide Rossi and Valeria Spina and Michaela Cerri and Silvia Rasi and Clara Deambrogi and \{De Paoli\}, Lorenzo and Luca Laurenti and Rossana Maffei and Francesco Forconi and Francesco Bertoni and Emanuele Zucca and Claudio Agostinelli and Antonello Cabras and Marco Lucioni and Maurizio Martini and Michele Magni and Silvia Deaglio and Marco Ladetto and Nomdedeu, \{Joseph F.\} and Caroline Besson and Antonio Ramponi and Vincenzo Canzonieri and Marco Paulli and Roberto Marasca and Larocca, \{Luigi Maria\} and Antonino Carbone and Pileri, \{Stefano A.\} and Valter Gattei and Gianluca Gaidano",

year = "2009",

doi = "10.1158/1078-0432.CCR-08-3266",

language = "English",

volume = "15",

pages = "4415--4422",

journal = "Clinical Cancer Research",

issn = "1078-0432",

publisher = "American Association for Cancer Research Inc.",

}

Rossi, D, Spina, V, Cerri, M, Rasi, S, Deambrogi, C, De Paoli, L, Laurenti, L, Maffei, R, Forconi, F, Bertoni, F, Zucca, E, Agostinelli, C, Cabras, A, Lucioni, M, Martini, M, Magni, M, Deaglio, S, Ladetto, M, Nomdedeu, JF, Besson, C, Ramponi, A, Canzonieri, V, Paulli, M, Marasca, R, Larocca, LM, Carbone, A, Pileri, SA, Gattei, V & Gaidano, G 2009, 'Stereotyped B-cell receptor is an independent risk factor of chronic lymphocytic leukemia transformation to Richter syndrome', Clinical Cancer Research, vol. 15, pp. 4415-4422. https://doi.org/10.1158/1078-0432.CCR-08-3266

TY - JOUR

T1 - Stereotyped B-cell receptor is an independent risk factor of chronic lymphocytic leukemia transformation to Richter syndrome

AU - Rossi, Davide

AU - Spina, Valeria

AU - Cerri, Michaela

AU - Rasi, Silvia

AU - Deambrogi, Clara

AU - De Paoli, Lorenzo

AU - Laurenti, Luca

AU - Maffei, Rossana

AU - Forconi, Francesco

AU - Bertoni, Francesco

AU - Zucca, Emanuele

AU - Agostinelli, Claudio

AU - Cabras, Antonello

AU - Lucioni, Marco

AU - Martini, Maurizio

AU - Magni, Michele

AU - Deaglio, Silvia

AU - Ladetto, Marco

AU - Nomdedeu, Joseph F.

AU - Besson, Caroline

AU - Ramponi, Antonio

AU - Canzonieri, Vincenzo

AU - Paulli, Marco

AU - Marasca, Roberto

AU - Larocca, Luigi Maria

AU - Carbone, Antonino

AU - Pileri, Stefano A.

AU - Gattei, Valter

AU - Gaidano, Gianluca

PY - 2009

Y1 - 2009

N2 - Few biological prognosticators are useful for prediction of Richter syndrome (RS), representing the transformation of chronic lymphocytic leukemia (CLL) to aggressive lymphoma. Stereotyped B-cell receptors (BCR) may have prognostic effect in CLL progression. We tested the prognostic effect of stereotyped BCR for predicting RS transformation.

AB - Few biological prognosticators are useful for prediction of Richter syndrome (RS), representing the transformation of chronic lymphocytic leukemia (CLL) to aggressive lymphoma. Stereotyped B-cell receptors (BCR) may have prognostic effect in CLL progression. We tested the prognostic effect of stereotyped BCR for predicting RS transformation.

KW - Aged

KW - Cohort Studies

KW - Disease Progression

KW - Female

KW - Gene Frequency

KW - Genetic Predisposition to Disease

KW - Humans

KW - Leukemia, Lymphocytic, Chronic, B-Cell

KW - Lymphoma

KW - Male

KW - Middle Aged

KW - Neoplasm Invasiveness

KW - Polymorphism, Genetic

KW - Proto-Oncogene Proteins c-bcr

KW - Risk Factors

KW - Syndrome

KW - Aged

KW - Cohort Studies

KW - Disease Progression

KW - Female

KW - Gene Frequency

KW - Genetic Predisposition to Disease

KW - Humans

KW - Leukemia, Lymphocytic, Chronic, B-Cell

KW - Lymphoma

KW - Male

KW - Middle Aged

KW - Neoplasm Invasiveness

KW - Polymorphism, Genetic

KW - Proto-Oncogene Proteins c-bcr

KW - Risk Factors

KW - Syndrome

UR - http://hdl.handle.net/10807/26203

U2 - 10.1158/1078-0432.CCR-08-3266

DO - 10.1158/1078-0432.CCR-08-3266

M3 - Article

SN - 1078-0432

VL - 15

SP - 4415

EP - 4422

JO - Clinical Cancer Research

JF - Clinical Cancer Research

ER -

Stereotyped B-cell receptor is an independent risk factor of chronic lymphocytic leukemia transformation to Richter syndrome

Abstract

Keywords

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