Abstract
This paper deals with the statistical properties of a response adaptive design, described in terms of a two colors urn model, targeting prespecified asymptotic allocations. Results on the rate of divergence of number of patients assigned to each treatment are proved as well as on the asymptotic behavior of the urn composition. Suitable statistics are introduced and studied to test the hypothesis on treatments' difference.
| Original language | English |
|---|---|
| Pages (from-to) | 708-737 |
| Number of pages | 30 |
| Journal | Electronic Journal of Statistics |
| Volume | 8 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2014 |
All Science Journal Classification (ASJC) codes
- Statistics and Probability
- Statistics, Probability and Uncertainty
Keywords
- Clinical trials
- Randomly reinforced urns
- Response adaptive designs
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