Specific oral tolerance induction (SOTI) in pediatric age: clinical research or just routine practice?

Stefano Miceli Sopo, Valentina Giorgio, Roberta Onesimo, Carlo Fundaro'

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Specific Oral Tolerance (SOTI) is a promising therapy of food allergy, specially for IgE-mediated cow milk allergy (CMA) in pediatric age. Randomized controlled trials have reported that about 35% of children, at least 5 years of age, became full tolerant to cow milk proteins after SOTI. Regard to the safety, literature describes about 200 children who underwent SOTI, with no fatal events. Nevertheless, a considerable percentage of those children (15%-20%) had to stop SOTI, because of important adverse effects. Numerous protocols have been described, some audacious and other prudent, however all demand an intense commitment either of the doctors and of the families. The information about the follow up of the children who underwent SOTI are still insufficient. For these reasons, we think that SOTI is still an experimental therapy.
Original languageEnglish
Pages (from-to)446-449
Number of pages4
JournalPediatric Allergy and Immunology
Volume21
DOIs
Publication statusPublished - 2010

Keywords

  • oral tolerance induction

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