Abstract

Sirt1, the closest mammalian homolog of the Sir2 yeast longevity protein, has been extensively investigated in the last few years as an avenue to understand the connection linking nutrients and energy metabolism with ageing and related diseases. From this research effort the picture has emerged of an enzyme at the hub of a complex array of molecular interactions whereby nutrient-triggered signals are translated into several levels of adaptive cell responses, the failure of which underlies diseases as diverse as diabetes, neurodegeneration and cancer. Sirt1 thus connects moderate calorie intake to "healthspan", and a decline of Sirt-centered protective circuits over time may explain the "catastrophic" nature of ageing.
Original languageEnglish
Pages (from-to)4135-4146
Number of pages11
JournalCELL CYCLE
Volume11
DOIs
Publication statusPublished - 2012

Keywords

  • AGING
  • CALORIE RESTRICTION
  • CREB
  • METABOLIC DISEASE
  • NUTRIENT SIGNALING
  • SIRT1

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