Signaling through estrogen receptors modulates long non-coding RNAs in prostate cancer

Prostate cancer (PCa) is a sex-steroid hormone-dependent cancer in which estrogens play a critical role in both\r\ninitiation and progression. Recently, several long non-coding RNAs (lncRNAs) have been associated with PCa\r\nand are supposedly playing a pivotal role in the biology and progression of this type of cancer. In this review, we\r\nfocused on some lncRNAs that are known for their androgen and estrogen transcriptional responsiveness in PCa.\r\nSpecifically, we summarized recent pieces of evidence about lncRNAs NEAT1, H19, MALAT1, and HOTAIR, in\r\nestrogen signaling, emphasizing their role in PCa progression and the acquisition of a castration-resistant phenotype.\r\nHere, the reader will find information about lncRNAs present in estrogen-dependent transcriptional\r\ncomplexes. The potential role of lncRNA/estrogen signaling as a novel pathway for PCa treatment will be discussed