Signaling through estrogen receptors modulates long non-coding RNAs in prostate cancer

Simona Nanni, Claudio Grassi, Alfredo Pontecorvi, Lorenza Bacci, Agnese Re, Chiara Salis, Aurora Aiello

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Prostate cancer (PCa) is a sex-steroid hormone-dependent cancer in which estrogens play a critical role in both initiation and progression. Recently, several long non-coding RNAs (lncRNAs) have been associated with PCa and are supposedly playing a pivotal role in the biology and progression of this type of cancer. In this review, we focused on some lncRNAs that are known for their androgen and estrogen transcriptional responsiveness in PCa. Specifically, we summarized recent pieces of evidence about lncRNAs NEAT1, H19, MALAT1, and HOTAIR, in estrogen signaling, emphasizing their role in PCa progression and the acquisition of a castration-resistant phenotype. Here, the reader will find information about lncRNAs present in estrogen-dependent transcriptional complexes. The potential role of lncRNA/estrogen signaling as a novel pathway for PCa treatment will be discussed
Original languageEnglish
Pages (from-to)N/A-N/A
Number of pages5
JournalMolecular and Cellular Endocrinology
Volume2020
DOIs
Publication statusPublished - 2020

Keywords

  • Aging
  • Biomarkers
  • Chronic disease
  • Estrogen receptor
  • Long non-coding RNAs
  • Metastasis
  • Prostate cancer
  • Transcription
  • Tumor progression

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