Short-course radiation versus long-course chemoradiation for rectal cancer

Bruce D. Minsky, Claus Rödel, Vincenzo Valentini

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The 2 broad approaches to preoperative therapy for rectal cancer are chemoradiation and short-course radiation. The outcomes of these 2 approaches reported in nonrandomized trials are not comparable because patients selected for treatment with short-course radiotherapy included those with cT1-3 disease, whereas patients selected for chemoradiation included those with T3 and/or N+ disease. However, more recent trials of short-course radiation have included patients with cT3 and/or N+ disease who also underwent sequential or postoperative chemotherapy, allowing a more relevant comparison with chemoradiation. This article compares the 2 preoperative approaches and addresses their emerging roles.
Original languageEnglish
Pages (from-to)1223-1231
Number of pages9
JournalJOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK
Volume10
DOIs
Publication statusPublished - 2012

Keywords

  • Carcinoma
  • Chemoradiotherapy, Adjuvant
  • Choice Behavior
  • Combined Modality Therapy
  • Digestive System Surgical Procedures
  • Humans
  • Radiotherapy Dosage
  • Radiotherapy, Adjuvant
  • Randomized Controlled Trials as Topic
  • Rectal Neoplasms
  • Time Factors

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