Short Communication: Proangiogenic Hematopoietic Cells In Acute HIV Infection

Luciana Teofili, Maurizio Martini, Maria Grazia Iachininoto, Sara Capodimonti, Eugenia Rosa Nuzzolo, Maria Bianchi, Katia Falasca, Claudio Ucciferri, Francesca Vignale, Eligio Pizzigallo, Jacopo Vecchiet

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Abstract Chronic HIV infection induces significant changes in the trafficking of circulating endothelial progenitor cells (EPCs). Specifically, it causes marked depletion of proangiogenic hematopoietic cells, the so-called colony-forming unit-endothelial cells (CFU-ECs). In this study we evaluated CFU-ECs in two subjects with acute HIV infection. We found that both patients already had a low CFU-EC level at the time of diagnosis. Nevertheless, after 6 months of antiretroviral therapy, the CFU-EC concentration reverted to normal values in both cases. HIV significantly depletes the CFU-EC compartment even in the early phase of infection, while 6-month therapy appears to be able to restore it.
Original languageEnglish
Pages (from-to)307-310
Number of pages4
JournalAIDS Research and Human Retroviruses
Volume29
DOIs
Publication statusPublished - 2013

Keywords

  • Endothelail progenitors
  • HIV

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