Severe veno-occlusive disease after autologous peripheral blood stem cell transplantation for high-grade non-Hodgkin lymphoma: report of a successfully managed case and a literature review of veno-occlusive disease.

Michele Palladino; Luca Miele; Maurizio Pompili; Alessandra Forgione; Valerio Gaetano Vellone; Fabio Maria Vecchio; Patrizia Chiusolo; Luca Laurenti; Giovanni Battista Gasbarrini; Simona Sica; Antonio Grieco

Severe veno-occlusive disease after autologous peripheral blood stem cell transplantation for high-grade non-Hodgkin lymphoma: report of a successfully managed case and a literature review of veno-occlusive disease.

Michele Palladino
, Luca Miele
, Maurizio Pompili
, Alessandra Forgione
, Valerio Gaetano Vellone
, Fabio Maria Vecchio
, Patrizia Chiusolo
, Luca Laurenti
, Giovanni Battista Gasbarrini
, Simona Sica
, Antonio Grieco

Research output: Contribution to journal › Article

Abstract

Veno-occlusive disease (VOD) of the liver is a severe complication of high-dose chemotherapy and allogeneic or autologous stem cell transplantation with potential fatal outcome. We report a case of severe VOD in a patient with a high-grade B-cell lymphoma. Liver-venule occlusion was confirmed by liver biopsy. Supportive care, fibrinolytic treatment with recombinant tissue plasminogen activator and defibrotide maintenance therapy led to complete resolution of VOD demonstrated at liver biopsy and with a follow-up of 44 months after autologous peripheral blood stem cell transplantation. The literature on VOD has been reviewed.

Original language	English
Pages (from-to)	837-841
Number of pages	5
Journal	Clinical Transplantation
Publication status	Published - 2008

Keywords

non Hodgkin
stem cells transplantation
therapy
veno occlusive disease

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Palladino, M., Miele, L., Pompili, M., Forgione, A., Vellone, V. G., Vecchio, F. M., Chiusolo, P., Laurenti, L., Gasbarrini, G. B., Sica, S., & Grieco, A. (2008). Severe veno-occlusive disease after autologous peripheral blood stem cell transplantation for high-grade non-Hodgkin lymphoma: report of a successfully managed case and a literature review of veno-occlusive disease. Clinical Transplantation, 837-841.

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title = "Severe veno-occlusive disease after autologous peripheral blood stem cell transplantation for high-grade non-Hodgkin lymphoma: report of a successfully managed case and a literature review of veno-occlusive disease.",

abstract = "Veno-occlusive disease (VOD) of the liver is a severe complication of high-dose chemotherapy and allogeneic or autologous stem cell transplantation with potential fatal outcome. We report a case of severe VOD in a patient with a high-grade B-cell lymphoma. Liver-venule occlusion was confirmed by liver biopsy. Supportive care, fibrinolytic treatment with recombinant tissue plasminogen activator and defibrotide maintenance therapy led to complete resolution of VOD demonstrated at liver biopsy and with a follow-up of 44 months after autologous peripheral blood stem cell transplantation. The literature on VOD has been reviewed.",

keywords = "non Hodgkin, stem cells transplantation, therapy, veno occlusive disease, non Hodgkin, stem cells transplantation, therapy, veno occlusive disease",

author = "Michele Palladino and Luca Miele and Maurizio Pompili and Alessandra Forgione and Vellone, \{Valerio Gaetano\} and Vecchio, \{Fabio Maria\} and Patrizia Chiusolo and Luca Laurenti and Gasbarrini, \{Giovanni Battista\} and Simona Sica and Antonio Grieco",

year = "2008",

language = "English",

pages = "837--841",

journal = "Clinical Transplantation",

issn = "0902-0063",

publisher = "Wiley-Blackwell Publishing Ltd",

}

Palladino, M, Miele, L , Pompili, M, Forgione, A, Vellone, VG, Vecchio, FM, Chiusolo, P , Laurenti, L, Gasbarrini, GB, Sica, S & Grieco, A 2008, 'Severe veno-occlusive disease after autologous peripheral blood stem cell transplantation for high-grade non-Hodgkin lymphoma: report of a successfully managed case and a literature review of veno-occlusive disease.', Clinical Transplantation, pp. 837-841.

Severe veno-occlusive disease after autologous peripheral blood stem cell transplantation for high-grade non-Hodgkin lymphoma: report of a successfully managed case and a literature review of veno-occlusive disease. / Palladino, Michele; Miele, Luca ; Pompili, Maurizio et al.
In: Clinical Transplantation, 2008, p. 837-841.

Research output: Contribution to journal › Article

TY - JOUR

T1 - Severe veno-occlusive disease after autologous peripheral blood stem cell transplantation for high-grade non-Hodgkin lymphoma: report of a successfully managed case and a literature review of veno-occlusive disease.

AU - Palladino, Michele

AU - Miele, Luca

AU - Pompili, Maurizio

AU - Forgione, Alessandra

AU - Vellone, Valerio Gaetano

AU - Vecchio, Fabio Maria

AU - Chiusolo, Patrizia

AU - Laurenti, Luca

AU - Gasbarrini, Giovanni Battista

AU - Sica, Simona

AU - Grieco, Antonio

PY - 2008

Y1 - 2008

N2 - Veno-occlusive disease (VOD) of the liver is a severe complication of high-dose chemotherapy and allogeneic or autologous stem cell transplantation with potential fatal outcome. We report a case of severe VOD in a patient with a high-grade B-cell lymphoma. Liver-venule occlusion was confirmed by liver biopsy. Supportive care, fibrinolytic treatment with recombinant tissue plasminogen activator and defibrotide maintenance therapy led to complete resolution of VOD demonstrated at liver biopsy and with a follow-up of 44 months after autologous peripheral blood stem cell transplantation. The literature on VOD has been reviewed.

AB - Veno-occlusive disease (VOD) of the liver is a severe complication of high-dose chemotherapy and allogeneic or autologous stem cell transplantation with potential fatal outcome. We report a case of severe VOD in a patient with a high-grade B-cell lymphoma. Liver-venule occlusion was confirmed by liver biopsy. Supportive care, fibrinolytic treatment with recombinant tissue plasminogen activator and defibrotide maintenance therapy led to complete resolution of VOD demonstrated at liver biopsy and with a follow-up of 44 months after autologous peripheral blood stem cell transplantation. The literature on VOD has been reviewed.

KW - non Hodgkin

KW - stem cells transplantation

KW - therapy

KW - veno occlusive disease

KW - non Hodgkin

KW - stem cells transplantation

KW - therapy

KW - veno occlusive disease

UR - http://hdl.handle.net/10807/16050

M3 - Article

SN - 0902-0063

SP - 837

EP - 841

JO - Clinical Transplantation

JF - Clinical Transplantation

ER -

Severe veno-occlusive disease after autologous peripheral blood stem cell transplantation for high-grade non-Hodgkin lymphoma: report of a successfully managed case and a literature review of veno-occlusive disease.

Abstract

Keywords

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