Severe veno-occlusive disease after autologous peripheral blood stem cell transplantation for high-grade non-Hodgkin lymphoma: report of a successfully managed case and a literature review of veno-occlusive disease.

Luca Miele, Maurizio Pompili, Patrizia Chiusolo, Luca Laurenti, Giovanni Battista Gasbarrini, Simona Sica, Antonio Grieco, Michele Palladino, Alessandra Forgione, Valerio Gaetano Vellone, Fabio Maria Vecchio

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2 Citations (Scopus)

Abstract

Veno-occlusive disease (VOD) of the liver is a severe complication of high-dose chemotherapy and allogeneic or autologous stem cell transplantation with potential fatal outcome. We report a case of severe VOD in a patient with a high-grade B-cell lymphoma. Liver-venule occlusion was confirmed by liver biopsy. Supportive care, fibrinolytic treatment with recombinant tissue plasminogen activator and defibrotide maintenance therapy led to complete resolution of VOD demonstrated at liver biopsy and with a follow-up of 44 months after autologous peripheral blood stem cell transplantation. The literature on VOD has been reviewed.
Original languageEnglish
Pages (from-to)837-841
Number of pages5
JournalClinical Transplantation
Publication statusPublished - 2008

Keywords

  • non Hodgkin
  • stem cells transplantation
  • therapy
  • veno occlusive disease

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