Severe sepsis in a premature neoante: protein C replacemnet therapy

Maria Pia De Carolis, Valentina Polimeni, Patrizia Papacci, Serafina Lacerenza, Costantino Romagnoli

Research output: Contribution to journalArticle

Abstract

Treatment with activated protein C has been shown to reduce mortality in adult patients with severe sepsis but also to increase risk of bleeding. In patients with predisposition to bleeding, as in preterm infants, the inactivated form of protein C could serve as a safe therapeutic option. We report the case of a preterm neonate who developed severe sepsis on the 28th day of life, who was successfully treated with the inactivated form of protein C for a period of 96 hours.
Original languageEnglish
Pages (from-to)405-408
Number of pages4
JournalTHE JOURNAL OF PEDIATRICS
Publication statusPublished - 2008

Keywords

  • Severe spepsis premature neonate
  • protein C

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