Severe disability in patients with relapsing-remitting multiple sclerosis is associated with profound changes in the regulation of leptin secretion

M Rotondi; Anna Paola Batocchi; F Coperchini; Marcella Caggiula; F Zerbini; R Sideri; P Leporati; Viviana Nociti; Giovanni Frisullo; Massimiliano Mirabella; F Magri; A Oliviero; L. Chiovato

doi:10.1159/000353567

Severe disability in patients with relapsing-remitting multiple sclerosis is associated with profound changes in the regulation of leptin secretion

M Rotondi
, Anna Paola Batocchi
, F Coperchini
, Marcella Caggiula
, F Zerbini
, R Sideri
, P Leporati
, Viviana Nociti
, Giovanni Frisullo
, Massimiliano Mirabella
, F Magri
, A Oliviero
, L. Chiovato

Ospedale Vito Fazzi
IRCCS Fondazione Don Carlo Gnocchi - Milano

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

Experimental evidences indicate that leptin is involved in the neuroinflammatory process sustaining multiple sclerosis (MS). However, the relationship between leptin and body fat, as assessed by body mass index (BMI), in MS was not previously evaluated. It was the aim of this study to compare serum leptin levels between patients with MS and healthy controls and to evaluate the possible relationship between circulating leptin levels and disease severity.

Original language	English
Pages (from-to)	341-347
Number of pages	7
Journal	NeuroImmunoModulation
Volume	20
Issue number	6
DOIs	https://doi.org/10.1159/000353567
Publication status	Published - 2013

All Science Journal Classification (ASJC) codes

Immunology
Endocrinology
Neurology
Endocrine and Autonomic Systems

Keywords

Adolescent
Adult
Aged
Body Mass Index
Disability Evaluation
Female
Humans
Leptin
Male
Middle Aged
Multiple Sclerosis
Relapsing-Remitting
Severity of Illness Index
Young Adult

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10.1159/000353567

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Rotondi, M., Batocchi, A. P., Coperchini, F., Caggiula, M., Zerbini, F., Sideri, R., Leporati, P., Nociti, V., Frisullo, G., Mirabella, M., Magri, F., Oliviero, A., & Chiovato, L. (2013). Severe disability in patients with relapsing-remitting multiple sclerosis is associated with profound changes in the regulation of leptin secretion. NeuroImmunoModulation, 20(6), 341-347. https://doi.org/10.1159/000353567

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title = "Severe disability in patients with relapsing-remitting multiple sclerosis is associated with profound changes in the regulation of leptin secretion",

abstract = "Experimental evidences indicate that leptin is involved in the neuroinflammatory process sustaining multiple sclerosis (MS). However, the relationship between leptin and body fat, as assessed by body mass index (BMI), in MS was not previously evaluated. It was the aim of this study to compare serum leptin levels between patients with MS and healthy controls and to evaluate the possible relationship between circulating leptin levels and disease severity.",

keywords = "Adolescent, Adult, Aged, Body Mass Index, Disability Evaluation, Female, Humans, Leptin, Male, Middle Aged, Multiple Sclerosis, Relapsing-Remitting, Severity of Illness Index, Young Adult, Adolescent, Adult, Aged, Body Mass Index, Disability Evaluation, Female, Humans, Leptin, Male, Middle Aged, Multiple Sclerosis, Relapsing-Remitting, Severity of Illness Index, Young Adult",

author = "M Rotondi and Batocchi, \{Anna Paola\} and F Coperchini and Marcella Caggiula and F Zerbini and R Sideri and P Leporati and Viviana Nociti and Giovanni Frisullo and Massimiliano Mirabella and F Magri and A Oliviero and L. Chiovato",

year = "2013",

doi = "10.1159/000353567",

language = "English",

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Rotondi, M, Batocchi, AP, Coperchini, F, Caggiula, M, Zerbini, F, Sideri, R, Leporati, P, Nociti, V, Frisullo, G, Mirabella, M, Magri, F, Oliviero, A & Chiovato, L 2013, 'Severe disability in patients with relapsing-remitting multiple sclerosis is associated with profound changes in the regulation of leptin secretion', NeuroImmunoModulation, vol. 20, no. 6, pp. 341-347. https://doi.org/10.1159/000353567

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AU - Rotondi, M

AU - Batocchi, Anna Paola

AU - Coperchini, F

AU - Caggiula, Marcella

AU - Zerbini, F

AU - Sideri, R

AU - Leporati, P

AU - Nociti, Viviana

AU - Frisullo, Giovanni

AU - Mirabella, Massimiliano

AU - Magri, F

AU - Oliviero, A

AU - Chiovato, L.

PY - 2013

Y1 - 2013

N2 - Experimental evidences indicate that leptin is involved in the neuroinflammatory process sustaining multiple sclerosis (MS). However, the relationship between leptin and body fat, as assessed by body mass index (BMI), in MS was not previously evaluated. It was the aim of this study to compare serum leptin levels between patients with MS and healthy controls and to evaluate the possible relationship between circulating leptin levels and disease severity.

AB - Experimental evidences indicate that leptin is involved in the neuroinflammatory process sustaining multiple sclerosis (MS). However, the relationship between leptin and body fat, as assessed by body mass index (BMI), in MS was not previously evaluated. It was the aim of this study to compare serum leptin levels between patients with MS and healthy controls and to evaluate the possible relationship between circulating leptin levels and disease severity.

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KW - Disability Evaluation

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KW - Humans

KW - Leptin

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KW - Humans

KW - Leptin

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KW - Middle Aged

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KW - Relapsing-Remitting

KW - Severity of Illness Index

KW - Young Adult

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ER -

Severe disability in patients with relapsing-remitting multiple sclerosis is associated with profound changes in the regulation of leptin secretion

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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