Severe anaphylaxis to sheep's milk cheese in a child desensitized to cow's milk through specific oral tolerance induction

Stefano Miceli Sopo, S. Tripodi, P. Comberiati, A. Di Rienzo Businco, A. Bianchi, F. Bondanini, V. Sargentini, G. Pingitore, C. Ballabio, P. Restani

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Specific oral tolerance induction to food (SOTI) is a new promising treatment for persistent IgE-mediated food allergy.Our paper reports a case of a 5-year-old girl with cow's milk allergy, who developed severe anaphylaxis after the ingestion of a croissant containing sheep's milk ricotta cheese, even though she had been previously desensitized to cow's milk through SOTI.The sheep's milk specific allergen causing the severe allergic reaction (a derivative of alpha-casein of 54,1kDa) was identified by SDS-PAGE and immunoblotting. We conclude that SOTI is a species-specific procedure and the induced tolerance to cow's milk doesn't necessarily provide protection against milk of other mammals. Therefore, children desensitized to cow's milk through SOTI should strictly avoid the intake of milk of other mammals, until tolerance to those kinds of milk is documented by an oral food challenge.
Original languageEnglish
Pages (from-to)56-60
Number of pages5
JournalEuropean Annals of Allergy and Clinical Immunology
Volume45
Publication statusPublished - 2013

Keywords

  • Cow's milk allergy
  • Food anaphylaxis
  • Immunoblotting
  • Oral food challenge
  • Sheep's milk allergy
  • Specific oral tolerance induction

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