Serum high-mobility group box-1 levels are positively associated with micro- and macroalbuminuria but not with cardiovascular disease in type 1 diabetes: the EURODIAB Prospective Complications Study

Jwm Nin; I Ferreira; Cg Schalkwijk; Mh Prins; N Chaturvedi; Jh Fuller; Cda Stehouwer; Eurodiab Prospective Complication Study; Angelo Maria Minnella

doi:10.1530/EJE-11-0662

Serum high-mobility group box-1 levels are positively associated with micro- and macroalbuminuria but not with cardiovascular disease in type 1 diabetes: the EURODIAB Prospective Complications Study

Jwm Nin^*
, I Ferreira
, Cg Schalkwijk
, Mh Prins
, N Chaturvedi
, Jh Fuller
, Cda Stehouwer
, Eurodiab Prospective Complication Study
, Angelo Maria Minnella

^*Corresponding author

Research output: Contribution to journal › Article

10 Citations (SciVal)

Abstract

High-mobility group box-1 (HMGB1) is a pro-inflammatory cytokine that may contribute to the pathogenesis of micro- and macrovascular complications commonly observed in diabetes. We investigated whether HMGB1 is associated with: i) markers of low-grade inflammation (LGI) and endothelial dysfunction (ED) and pulse pressure (PP, a marker of arterial stiffness); ii) prevalent nephropathy, retinopathy and cardiovascular disease (CVD) in type 1 diabetes; and iii) the potential mediating roles of LGI, ED and PP therein.

Original language	English
Pages (from-to)	325-332
Number of pages	8
Journal	European Journal of Endocrinology
Volume	166
Issue number	2
DOIs	https://doi.org/10.1530/EJE-11-0662
Publication status	Published - 2012

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Endocrinology, Diabetes and Metabolism
Endocrinology

Keywords

Adult
Albuminuria
Biological Markers
Cardiovascular Diseases
Case-Control Studies
Cross-Sectional Studies
Diabetes Complications
Diabetes Mellitus
Europe
Female
Glomerular Filtration Rate
HMGB1 Protein
Humans
Male
Middle Aged
Risk Factors
Severity of Illness Index
Type 1

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10.1530/EJE-11-0662

Cite this

Nin, J., Ferreira, I., Schalkwijk, C., Prins, M., Chaturvedi, N., Fuller, J., Stehouwer, C., Study, E. P. C., & Minnella, A. M. (2012). Serum high-mobility group box-1 levels are positively associated with micro- and macroalbuminuria but not with cardiovascular disease in type 1 diabetes: the EURODIAB Prospective Complications Study. European Journal of Endocrinology, 166(2), 325-332. https://doi.org/10.1530/EJE-11-0662

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title = "Serum high-mobility group box-1 levels are positively associated with micro- and macroalbuminuria but not with cardiovascular disease in type 1 diabetes: the EURODIAB Prospective Complications Study",

abstract = "High-mobility group box-1 (HMGB1) is a pro-inflammatory cytokine that may contribute to the pathogenesis of micro- and macrovascular complications commonly observed in diabetes. We investigated whether HMGB1 is associated with: i) markers of low-grade inflammation (LGI) and endothelial dysfunction (ED) and pulse pressure (PP, a marker of arterial stiffness); ii) prevalent nephropathy, retinopathy and cardiovascular disease (CVD) in type 1 diabetes; and iii) the potential mediating roles of LGI, ED and PP therein.",

keywords = "Adult, Albuminuria, Biological Markers, Cardiovascular Diseases, Case-Control Studies, Cross-Sectional Studies, Diabetes Complications, Diabetes Mellitus, Europe, Female, Glomerular Filtration Rate, HMGB1 Protein, Humans, Male, Middle Aged, Risk Factors, Severity of Illness Index, Type 1, Adult, Albuminuria, Biological Markers, Cardiovascular Diseases, Case-Control Studies, Cross-Sectional Studies, Diabetes Complications, Diabetes Mellitus, Europe, Female, Glomerular Filtration Rate, HMGB1 Protein, Humans, Male, Middle Aged, Risk Factors, Severity of Illness Index, Type 1",

author = "Jwm Nin and I Ferreira and Cg Schalkwijk and Mh Prins and N Chaturvedi and Jh Fuller and Cda Stehouwer and Study, \{Eurodiab Prospective Complication\} and Minnella, \{Angelo Maria\}",

year = "2012",

doi = "10.1530/EJE-11-0662",

language = "English",

volume = "166",

pages = "325--332",

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Nin, J, Ferreira, I, Schalkwijk, C, Prins, M, Chaturvedi, N, Fuller, J, Stehouwer, C, Study, EPC & Minnella, AM 2012, 'Serum high-mobility group box-1 levels are positively associated with micro- and macroalbuminuria but not with cardiovascular disease in type 1 diabetes: the EURODIAB Prospective Complications Study', European Journal of Endocrinology, vol. 166, no. 2, pp. 325-332. https://doi.org/10.1530/EJE-11-0662

Serum high-mobility group box-1 levels are positively associated with micro- and macroalbuminuria but not with cardiovascular disease in type 1 diabetes: the EURODIAB Prospective Complications Study. / Nin, Jwm; Ferreira, I; Schalkwijk, Cg et al.
In: European Journal of Endocrinology, Vol. 166, No. 2, 2012, p. 325-332.

Research output: Contribution to journal › Article

TY - JOUR

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AU - Nin, Jwm

AU - Ferreira, I

AU - Schalkwijk, Cg

AU - Prins, Mh

AU - Chaturvedi, N

AU - Fuller, Jh

AU - Stehouwer, Cda

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AU - Minnella, Angelo Maria

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AB - High-mobility group box-1 (HMGB1) is a pro-inflammatory cytokine that may contribute to the pathogenesis of micro- and macrovascular complications commonly observed in diabetes. We investigated whether HMGB1 is associated with: i) markers of low-grade inflammation (LGI) and endothelial dysfunction (ED) and pulse pressure (PP, a marker of arterial stiffness); ii) prevalent nephropathy, retinopathy and cardiovascular disease (CVD) in type 1 diabetes; and iii) the potential mediating roles of LGI, ED and PP therein.

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KW - Cardiovascular Diseases

KW - Case-Control Studies

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KW - Risk Factors

KW - Severity of Illness Index

KW - Type 1

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KW - Diabetes Mellitus

KW - Europe

KW - Female

KW - Glomerular Filtration Rate

KW - HMGB1 Protein

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KW - Male

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U2 - 10.1530/EJE-11-0662

DO - 10.1530/EJE-11-0662

M3 - Article

SN - 0804-4643

VL - 166

SP - 325

EP - 332

JO - European Journal of Endocrinology

JF - European Journal of Endocrinology

IS - 2

ER -

Serum high-mobility group box-1 levels are positively associated with micro- and macroalbuminuria but not with cardiovascular disease in type 1 diabetes: the EURODIAB Prospective Complications Study

Abstract

UN SDGs

All Science Journal Classification (ASJC) codes

Keywords

Access to Document

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