Serum high-mobility group box-1 levels are positively associated with micro- and macroalbuminuria but not with cardiovascular disease in type 1 diabetes: the EURODIAB Prospective Complications Study

Angelo Maria Minnella, Jwm Nin, I Ferreira, Cg Schalkwijk, Mh Prins, N Chaturvedi, Jh Fuller, Cda Stehouwer, Eurodiab Prospective Complication Study

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

High-mobility group box-1 (HMGB1) is a pro-inflammatory cytokine that may contribute to the pathogenesis of micro- and macrovascular complications commonly observed in diabetes. We investigated whether HMGB1 is associated with: i) markers of low-grade inflammation (LGI) and endothelial dysfunction (ED) and pulse pressure (PP, a marker of arterial stiffness); ii) prevalent nephropathy, retinopathy and cardiovascular disease (CVD) in type 1 diabetes; and iii) the potential mediating roles of LGI, ED and PP therein.
Original languageEnglish
Pages (from-to)325-332
Number of pages8
JournalEuropean Journal of Endocrinology
Volume166
DOIs
Publication statusPublished - 2012

Keywords

  • Adult
  • Albuminuria
  • Biological Markers
  • Cardiovascular Diseases
  • Case-Control Studies
  • Cross-Sectional Studies
  • Diabetes Complications
  • Diabetes Mellitus, Type 1
  • Europe
  • Female
  • Glomerular Filtration Rate
  • HMGB1 Protein
  • Humans
  • Male
  • Middle Aged
  • Risk Factors
  • Severity of Illness Index

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