Serum amyloid-A in Behçet's disease.

Antonio Vitale, Donato Rigante, Giuseppe Lopalco, Maria Giuseppina Brizi, Francesco Caso, Rossella Franceschini, Rosario Denaro, Mauro Galeazzi, Leonardo Punzi, Florenzo Iannone, Giovanni Lapadula, Antonella Simpatico, Edoardo Marrani, Luisa Costa, Rolando Cimaz, Luca Cantarini

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Serum amyloid-A (SAA) is an acute phase protein, synthesized by the liver and previously investigated as a marker of disease activity in many rheumatologic disorders. Its significance in Behçet’s disease (BD), a chronic inflammatory disorder at the crossroad between autoimmune and autoinflammatory syndromes, is still unraveled. Our aim was to assess the role of SAA levels as a potential marker of disease activity in patients with BD. According to our findings, the occurrence of oral aphthosis, neurological impairment, and ocular disease is significantly associated with SAA serum levels higher than 30, 50, and 150 mg/L, respectively. We also suggest that increased SAA levels might identify a thrombotic risk in BD with previous or concurrent vascular involvement.
Original languageEnglish
Pages (from-to)1165-1167
Number of pages3
JournalClinical Rheumatology
Volume33
DOIs
Publication statusPublished - 2014

Keywords

  • Behçet's disease
  • Serum amyloid-A

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