Seroprevalence of anti-SARS-CoV-2 IgG antibodies in children with household exposure to adults with COVID-19: Preliminary findings

Piero Valentini, Francesco Landi, Ivana Palucci, Maurizio Sanguinetti, Michela Sali, Paola Cattani, Luca Richeldi, Danilo Buonsenso, Cristina De Rose, Davide Pata, Dario Sinatti, Domenico Speziale, Flavio De Maio, F. Landi, R. Bernabei, A. Gasbarrini, C. R. Settanni, F. Benvenuto, G. Bramato, A. CarfìF. Ciciarello, M. R. Lo Monaco, A. M. Martone, C. Napolitano, F. Pagano, S. Rocchi, E. Rota, A. Salerno, M. Tosato, M. Tritto, R. Calvani, L. Catalano, A. Picca, G. Savera, A. Borghetti, S. Di Gianbenedetto, R. Murri, A. Cingolani, E. Taddei, D. Moschese, A. Ciccullo, L. Stella, M. A. Zocco, S. Marchetti, M. Sali, A. Bizzarro, A. Lauria, S. Rizzo, M. C. Savastano, G. Gambini, G. M. Cozzupoli, C. Culiersi, J. Galli, F. Crudo, G. Di Cintio, Y. Longobardi, L. Tricarico, M. Santantonio, D. Buonsenso, P. Valentini, D. Pata, D. Sinatti, C. De Rose, F. Lombardi, A. Calabrese, D. Janiri, G. Giuseppin, M. Molinaro, M. Modica, L. Natale, R. Marano, A. Paglionico, L. Petricca, L. Gigante, G. Natalello, A. L. Fedele, M. M. Lizzio, B. Tolusso, L. Santoro, A. Nesci, V. Popolla

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Weather and the susceptibility of children to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is still a debated question and currently a hot topic, particularly in view of important decisions regarding opening schools. Therefore, we performed this prospective analysis of anti-SARS-CoV-2 immunoglobulin G (IgG) antibodies in children with known household exposure to SARS-CoV-2 and compared their IgG status with the other adults exposed to the index case in the same household. A total of 30 families with a documented COVID-19 index case were included. A total of 44 out of 80 household contacts (55%) of index patients had anti SARS-CoV-2 IgG antibodies. In particular, 16/27 (59,3%) adult partners had IgG antibodies compared with 28/53 (52,3%) of pediatric contacts (p >.05). Among the pediatric population, children ≥5 years of age had a similar probability of having SARS-CoV-2 IgG antibodies (21/39, 53.8%) compared to those less than 5 years old (7/14, 50%) (p >.05). Adult partners and children also had a similar probability of having SARS-CoV-2 IgG antibodies. Interestingly, 10/28 (35.7%) of children and 5/27 (18.5%) of adults with SARS-CoV-2 IgG antibodies were previously diagnosed as COVID-19 cases. Our study shows evidence of a high rate of IgG antibodies in children exposed to SARS-CoV-2. This report has public health implications, highlighting the need to establish appropriate guidelines for school openings and other social activities related to childhood.
Original languageEnglish
Pages (from-to)N/A-N/A
JournalPediatric Pulmonology
Publication statusPublished - 2020


  • COVID-19
  • SARS-CoV-2
  • children
  • household
  • seroprevalence


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