Semaphorins as emerging clinical biomarkers and therapeutic targets in cancer

Roberta Mastrantonio, Luca Tamagnone, Hua You

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Semaphorins are a large family of developmental regulatory signals, characterized by aberrant expression in human cancers. These molecules crucially control cell-cell communication, cell migration, invasion and metastasis, tumor angiogenesis, inflammatory and anti-cancer immune responses. Semaphorins comprise secreted and cell surface-exposed molecules and their receptors are mainly found in the Plexin and Neuropilin families, which are further implicated in a signaling network controlling the tumor microenvironment. Accumulating evidence indicates that semaphorins may be considered as novel clinical biomarkers for cancer, especially for the prediction of patient survival and responsiveness to therapy. Moreover, preclinical experimental studies have demonstrated that targeting semaphorin signaling can interfere with tumor growth and/or metastatic dissemination, suggesting their relevance as novel therapeutic targets in cancer; this has also prompted the development of semaphorin-interfering molecules for application in the clinic. Here we will survey, in diverse human cancers, the current knowledge about the relevance of semaphorin family members, and conceptualize potential lines of future research development in this field.
Original languageEnglish
Pages (from-to)3262-3277
Number of pages16
JournalTheranostics
Volume15
DOIs
Publication statusPublished - 2021

Keywords

  • cancer
  • neuropilin
  • plexin
  • predictive biomarkers
  • prognostic biomarkers
  • semaphorin
  • therapy.

Fingerprint Dive into the research topics of 'Semaphorins as emerging clinical biomarkers and therapeutic targets in cancer'. Together they form a unique fingerprint.

Cite this