Safety and efficacy of abobotulinumtoxinA for hemiparesis in adults with upper limb spasticity after stroke or traumatic brain injury: a double-blind randomised controlled trial

Anna Rita Bentivoglio, Jean-Michel Gracies, Allison Brashear, Robert Jech, Peter Mcallister, Marta Banach, Peter Valkovic, Heather Walker, Christina Marciniak, Thierry Deltombe, Alexander Skoromets, Svetlana Khatkova, Steven Edgley, Fatma Gul, France Catus, Beatrice Bois De Fer, Claire Vilain, Philippe Picaut, Z. Ayyoub, D. BensmailA. R Bentivoglio, F. Boyer, A. Csanyi, Z. Denes, P. Hedera, S. Isaacson, M. E. Isner-Horobeti, A. Kaminska, S. Kocer, T. Lejeune, P. Marque, M. O'Dell, O. Remy-Neris, B. Rubin, M. Rudzinska, D. Simpson, S. L. Timerbaeva, M. Vecchio, M. Wimmer

Research output: Contribution to journalArticle

98 Citations (Scopus)

Abstract

Resistance from antagonistic muscle groups might be a crucial factor reducing function in chronic hemiparesis. The resistance due to spastic co-contraction might be reduced by botulinum toxin injections. We assessed the effects of abobotulinumtoxinA injection in the upper limb muscles on muscle tone, spasticity, active movement, and function.
Original languageEnglish
Pages (from-to)992-1001
Number of pages10
JournalThe Lancet
Volume14
DOIs
Publication statusPublished - 2015

Keywords

  • Acetylcholine Release Inhibitors
  • Adult
  • Botulinum Toxins, Type A
  • Brain Injuries
  • Double-Blind Method
  • Female
  • Humans
  • Injections, Intramuscular
  • Male
  • Middle Aged
  • Muscle Spasticity
  • Paresis
  • Stroke
  • Treatment Outcome
  • Upper Extremity

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