Role of the complement in pregnancy with antiphospholipid syndrome: Mechanisms of pathogenesis and clinical aspects

Sara De Carolis, Serafina Garofalo, Silvia Salvi, Angela Botta

Research output: Contribution to journalArticle

Abstract

Antiphospholipid syndrome is a disease that was discovered just 25 years ago. Although clinical manifestations have been clearly described, pathogenetic mechanisms are still barely understood. A recent hypothesis involves inflammation in the setting of antiphospholipid syndrome morbidity and experimental data support the activation of a complement cascade as a pivotal event in its physiopathology. In this review, the authors will analyze the recent literature, focusing on contemporary and emerging aspects of complement-mediated disease pathogenesis, and pinpoint the clinical significance of this novel finding. © 2013 Future Medicine Ltd.
Original languageEnglish
Pages (from-to)399-405
Number of pages7
JournalInternational Journal of Clinical Rheumatology
Volume8
DOIs
Publication statusPublished - 2013

Keywords

  • adverse pregnancy outcome
  • antiphospholipid syndrome
  • complement pathway
  • hypocomplementemia

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