TY - JOUR
T1 - Role of SOCS3 evaluated by immunohistochemical analysis in a cohort of patients affected by prostate cancer: preliminary results
AU - Calarco, Alessandro
AU - Pinto, Francesco
AU - Pierconti, Francesco
AU - Sacco, Emilio
AU - Marrucci, Eleonora
AU - Totaro, Angelo
AU - Palermo, Giuseppe
AU - Vittori, Matteo
AU - Bassi, Pierfrancesco
PY - 2012
Y1 - 2012
N2 - Chronic inflammation may play a role in prostate carcinogenesis. Molecular alterations of the Suppressor of Cytokine Signaling (SOCS)-3 can contribute to explain the pleiotropic role of interleukin (IL)-6 in this type of cancer. Recently, the methylation of SOCS3 gene has been demonstrated to cause the non-expression of the protein, being involved in the pathogenesis of prostate cancer (PC) and identifying a subset of aggressive tumors. We evaluated the expression of SOCS3 protein in patients (pt) with bioptically-diagnosed PC by immunohistochemical analysis, which is easier to perform, cheaper and more reproducible compared to DNA analysis.
AB - Chronic inflammation may play a role in prostate carcinogenesis. Molecular alterations of the Suppressor of Cytokine Signaling (SOCS)-3 can contribute to explain the pleiotropic role of interleukin (IL)-6 in this type of cancer. Recently, the methylation of SOCS3 gene has been demonstrated to cause the non-expression of the protein, being involved in the pathogenesis of prostate cancer (PC) and identifying a subset of aggressive tumors. We evaluated the expression of SOCS3 protein in patients (pt) with bioptically-diagnosed PC by immunohistochemical analysis, which is easier to perform, cheaper and more reproducible compared to DNA analysis.
KW - prostate cancer
KW - prostate cancer
UR - http://hdl.handle.net/10807/62770
U2 - 10.5301/RU.2012.9392
DO - 10.5301/RU.2012.9392
M3 - Article
SN - 0391-5603
VL - 79 Suppl 19
SP - 4
EP - 8
JO - Urologia
JF - Urologia
ER -
