Role of HSV-1 in Alzheimer's disease pathogenesis: A challenge for novel preventive/therapeutic strategies

Virginia Protto; Maria Elena Marcocci; Mariya Timotey Miteva; Roberto Piacentini; Domenica Donatella Li Puma; Claudio Grassi; Anna Teresa Palamara; Giovanna De Chiara

doi:10.1016/j.coph.2022.102200

Role of HSV-1 in Alzheimer's disease pathogenesis: A challenge for novel preventive/therapeutic strategies

Virginia Protto, Maria Elena Marcocci, Mariya Timotey Miteva, Roberto Piacentini, Domenica Donatella Li Puma, Claudio Grassi, Anna Teresa Palamara, Giovanna De Chiara^*

^*Corresponding author

Research output: Contribution to journal › Article › peer-review

Abstract

Herpes simplex virus-1 (HSV-1) is a ubiquitous DNA virus able to establish a life-long latent infection in host sensory ganglia. Following periodic reactivations, the neovirions usually target the site of primary infection causing recurrent diseases in susceptible individuals. However, reactivated HSV-1 may also reach the brain resulting in severe herpetic encephalitis or in asymptomatic infections. These have been reportedly linked to neurodegenerative disorders, such as Alzheimer's disease (AD), suggesting antiviral preventive or/therapeutic treatments as possible strategies to counteract AD onset and progression. Here, we provide an overview of the AD-like mechanisms driven by HSV-1-infection in neurons and discuss the ongoing trials repurposing anti-herpetic drugs to treat AD as well as preventive strategies aimed at blocking virus infection.

Original language	English
Pages (from-to)	N/A-N/A
Number of pages	6
Journal	Current Opinion in Pharmacology
Volume	63
DOIs	https://doi.org/10.1016/j.coph.2022.102200
Publication status	Published - 2022

Keywords

Alzheimer Disease
Brain
Herpes Simplex
Herpesvirus 1, Human
Humans
Neurons

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.coph.2022.102200

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@article{e5a442d689ce412fa7a13b14af5828df,

title = "Role of HSV-1 in Alzheimer's disease pathogenesis: A challenge for novel preventive/therapeutic strategies",

abstract = "Herpes simplex virus-1 (HSV-1) is a ubiquitous DNA virus able to establish a life-long latent infection in host sensory ganglia. Following periodic reactivations, the neovirions usually target the site of primary infection causing recurrent diseases in susceptible individuals. However, reactivated HSV-1 may also reach the brain resulting in severe herpetic encephalitis or in asymptomatic infections. These have been reportedly linked to neurodegenerative disorders, such as Alzheimer's disease (AD), suggesting antiviral preventive or/therapeutic treatments as possible strategies to counteract AD onset and progression. Here, we provide an overview of the AD-like mechanisms driven by HSV-1-infection in neurons and discuss the ongoing trials repurposing anti-herpetic drugs to treat AD as well as preventive strategies aimed at blocking virus infection.",

keywords = "Alzheimer Disease, Brain, Herpes Simplex, Herpesvirus 1, Human, Humans, Neurons, Alzheimer Disease, Brain, Herpes Simplex, Herpesvirus 1, Human, Humans, Neurons",

author = "Virginia Protto and Marcocci, {Maria Elena} and Miteva, {Mariya Timotey} and Roberto Piacentini and {Li Puma}, {Domenica Donatella} and Claudio Grassi and Palamara, {Anna Teresa} and {De Chiara}, Giovanna",

year = "2022",

doi = "10.1016/j.coph.2022.102200",

language = "English",

volume = "63",

pages = "N/A--N/A",

journal = "Current Opinion in Pharmacology",

issn = "1471-4892",

publisher = "Elsevier BV:PO Box 211, 1000 AE Amsterdam Netherlands:011 31 20 4853757, 011 31 20 4853642, 011 31 20 4853641, EMAIL: [email protected], INTERNET: http://www.elsevier.nl, Fax: 011 31 20 4853598",

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TY - JOUR

T1 - Role of HSV-1 in Alzheimer's disease pathogenesis: A challenge for novel preventive/therapeutic strategies

AU - Protto, Virginia

AU - Marcocci, Maria Elena

AU - Miteva, Mariya Timotey

AU - Piacentini, Roberto

AU - Li Puma, Domenica Donatella

AU - Grassi, Claudio

AU - Palamara, Anna Teresa

AU - De Chiara, Giovanna

PY - 2022

Y1 - 2022

N2 - Herpes simplex virus-1 (HSV-1) is a ubiquitous DNA virus able to establish a life-long latent infection in host sensory ganglia. Following periodic reactivations, the neovirions usually target the site of primary infection causing recurrent diseases in susceptible individuals. However, reactivated HSV-1 may also reach the brain resulting in severe herpetic encephalitis or in asymptomatic infections. These have been reportedly linked to neurodegenerative disorders, such as Alzheimer's disease (AD), suggesting antiviral preventive or/therapeutic treatments as possible strategies to counteract AD onset and progression. Here, we provide an overview of the AD-like mechanisms driven by HSV-1-infection in neurons and discuss the ongoing trials repurposing anti-herpetic drugs to treat AD as well as preventive strategies aimed at blocking virus infection.

AB - Herpes simplex virus-1 (HSV-1) is a ubiquitous DNA virus able to establish a life-long latent infection in host sensory ganglia. Following periodic reactivations, the neovirions usually target the site of primary infection causing recurrent diseases in susceptible individuals. However, reactivated HSV-1 may also reach the brain resulting in severe herpetic encephalitis or in asymptomatic infections. These have been reportedly linked to neurodegenerative disorders, such as Alzheimer's disease (AD), suggesting antiviral preventive or/therapeutic treatments as possible strategies to counteract AD onset and progression. Here, we provide an overview of the AD-like mechanisms driven by HSV-1-infection in neurons and discuss the ongoing trials repurposing anti-herpetic drugs to treat AD as well as preventive strategies aimed at blocking virus infection.

KW - Alzheimer Disease

KW - Brain

KW - Herpes Simplex

KW - Herpesvirus 1, Human

KW - Humans

KW - Neurons

KW - Alzheimer Disease

KW - Brain

KW - Herpes Simplex

KW - Herpesvirus 1, Human

KW - Humans

KW - Neurons

UR - http://hdl.handle.net/10807/202585

U2 - 10.1016/j.coph.2022.102200

DO - 10.1016/j.coph.2022.102200

M3 - Article

SN - 1471-4892

VL - 63

SP - N/A-N/A

JO - Current Opinion in Pharmacology

JF - Current Opinion in Pharmacology

ER -

Role of HSV-1 in Alzheimer's disease pathogenesis: A challenge for novel preventive/therapeutic strategies

Abstract

Keywords

UN SDGs

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