Risk of acute promyelocytic leukemia in multiple sclerosis: coding variants of DNA repair genes

S. K. Hasan; F. Buttari; T. Ottone; Maria Teresa Voso; Stefan Hohaus; E. Marasco; V. Mantovani; P. Garagnani; M. A. Sanz; L. Cicconi; G. Bernardi; D. Centonze; F. Lo-Coco

doi:10.1212/WNL.0b013e318211c3c8

Risk of acute promyelocytic leukemia in multiple sclerosis: coding variants of DNA repair genes

S. K. Hasan
, F. Buttari
, T. Ottone
, Maria Teresa Voso
, Stefan Hohaus
, E. Marasco
, V. Mantovani
, P. Garagnani
, M. A. Sanz
, L. Cicconi
, G. Bernardi
, D. Centonze
, F. Lo-Coco

Clinica Neurologica
University of Rome Tor Vergata
Alma Mater Studiorum University of Bologna
Hospital Universitario La Fe

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

Abstract

Single nucleotide polymorphisms (SNPs) in double-strand break repair genes may alter DNA repair capacity and, in turn, confer predisposition to leukemia. We analyzed polymorphic variants of DNA repair and detoxification genes in patients with multiple sclerosis (MS) who developed secondary acute promyelocytic leukemia (sAPL), in most cases after treatment with mitoxantrone (MTZ).

Original language	English
Pages (from-to)	1059-1065
Number of pages	7
Journal	Neurology
Volume	76
DOIs	https://doi.org/10.1212/WNL.0b013e318211c3c8
Publication status	Published - 2011

Keywords

Antineoplastic Agents
DNA Repair Enzymes
Genetic Predisposition to Disease
Humans
Leukemia, Promyelocytic, Acute
Mitoxantrone
Multiple Sclerosis
Polymorphism, Single Nucleotide
Risk Factors

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title = "Risk of acute promyelocytic leukemia in multiple sclerosis: coding variants of DNA repair genes",

abstract = "Single nucleotide polymorphisms (SNPs) in double-strand break repair genes may alter DNA repair capacity and, in turn, confer predisposition to leukemia. We analyzed polymorphic variants of DNA repair and detoxification genes in patients with multiple sclerosis (MS) who developed secondary acute promyelocytic leukemia (sAPL), in most cases after treatment with mitoxantrone (MTZ).",

keywords = "Antineoplastic Agents, DNA Repair Enzymes, Genetic Predisposition to Disease, Humans, Leukemia, Promyelocytic, Acute, Mitoxantrone, Multiple Sclerosis, Polymorphism, Single Nucleotide, Risk Factors, Antineoplastic Agents, DNA Repair Enzymes, Genetic Predisposition to Disease, Humans, Leukemia, Promyelocytic, Acute, Mitoxantrone, Multiple Sclerosis, Polymorphism, Single Nucleotide, Risk Factors",

author = "Hasan, \{S. K.\} and F. Buttari and T. Ottone and Voso, \{Maria Teresa\} and Stefan Hohaus and E. Marasco and V. Mantovani and P. Garagnani and Sanz, \{M. A.\} and L. Cicconi and G. Bernardi and D. Centonze and F. Lo-Coco",

year = "2011",

doi = "10.1212/WNL.0b013e318211c3c8",

language = "English",

volume = "76",

pages = "1059--1065",

journal = "Neurology",

issn = "0028-3878",

publisher = "Lippincott Williams and Wilkins",

}

TY - JOUR

T1 - Risk of acute promyelocytic leukemia in multiple sclerosis: coding variants of DNA repair genes

AU - Hasan, S. K.

AU - Buttari, F.

AU - Ottone, T.

AU - Voso, Maria Teresa

AU - Hohaus, Stefan

AU - Marasco, E.

AU - Mantovani, V.

AU - Garagnani, P.

AU - Sanz, M. A.

AU - Cicconi, L.

AU - Bernardi, G.

AU - Centonze, D.

AU - Lo-Coco, F.

PY - 2011

Y1 - 2011

N2 - Single nucleotide polymorphisms (SNPs) in double-strand break repair genes may alter DNA repair capacity and, in turn, confer predisposition to leukemia. We analyzed polymorphic variants of DNA repair and detoxification genes in patients with multiple sclerosis (MS) who developed secondary acute promyelocytic leukemia (sAPL), in most cases after treatment with mitoxantrone (MTZ).

AB - Single nucleotide polymorphisms (SNPs) in double-strand break repair genes may alter DNA repair capacity and, in turn, confer predisposition to leukemia. We analyzed polymorphic variants of DNA repair and detoxification genes in patients with multiple sclerosis (MS) who developed secondary acute promyelocytic leukemia (sAPL), in most cases after treatment with mitoxantrone (MTZ).

KW - Antineoplastic Agents

KW - DNA Repair Enzymes

KW - Genetic Predisposition to Disease

KW - Humans

KW - Leukemia, Promyelocytic, Acute

KW - Mitoxantrone

KW - Multiple Sclerosis

KW - Polymorphism, Single Nucleotide

KW - Risk Factors

KW - Antineoplastic Agents

KW - DNA Repair Enzymes

KW - Genetic Predisposition to Disease

KW - Humans

KW - Leukemia, Promyelocytic, Acute

KW - Mitoxantrone

KW - Multiple Sclerosis

KW - Polymorphism, Single Nucleotide

KW - Risk Factors

UR - http://hdl.handle.net/10807/11661

U2 - 10.1212/WNL.0b013e318211c3c8

DO - 10.1212/WNL.0b013e318211c3c8

M3 - Article

SN - 0028-3878

VL - 76

SP - 1059

EP - 1065

JO - Neurology

JF - Neurology

ER -

Risk of acute promyelocytic leukemia in multiple sclerosis: coding variants of DNA repair genes

Abstract

Keywords

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