Risk of acute promyelocytic leukemia in multiple sclerosis: coding variants of DNA repair genes

S. K. Hasan, F. Buttari, T. Ottone, Maria Teresa Voso, Stefan Hohaus, E. Marasco, V. Mantovani, P. Garagnani, M. A. Sanz, L. Cicconi, G. Bernardi, D. Centonze, F. Lo-Coco

Research output: Contribution to journalArticlepeer-review

29 Citations (Scopus)

Abstract

Single nucleotide polymorphisms (SNPs) in double-strand break repair genes may alter DNA repair capacity and, in turn, confer predisposition to leukemia. We analyzed polymorphic variants of DNA repair and detoxification genes in patients with multiple sclerosis (MS) who developed secondary acute promyelocytic leukemia (sAPL), in most cases after treatment with mitoxantrone (MTZ).
Original languageEnglish
Pages (from-to)1059-1065
Number of pages7
JournalNeurology
Volume76
DOIs
Publication statusPublished - 2011

Keywords

  • Antineoplastic Agents
  • DNA Repair Enzymes
  • Genetic Predisposition to Disease
  • Humans
  • Leukemia, Promyelocytic, Acute
  • Mitoxantrone
  • Multiple Sclerosis
  • Polymorphism, Single Nucleotide
  • Risk Factors

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